Results 221 to 230 of about 122,430 (279)

Extracellular Vesicle‐Based mRNA Therapeutics and Vaccines

Exploration, EarlyView.
This review provides a comprehensive analysis of recent advancements in extracellular vesicle (EV)‐based messenger RNA (mRNA) applications for therapeutics and vaccines. It systematically outlines strategies for mRNA encapsulation within EVs and elucidates the challenges associated with this technology, offering insights into future research directions
Qi Li, Haonan Xing, Abid Naeem, Kaiyue Zhang, Aiping Zheng, Yuanyu Huang, Mei Lu   +6 more
wiley   +1 more source

Modulation of Gut Microbiota by Protein‐Oligosaccharide Maillard‐Reaction‐Derived Probiotic Microcapsules

Food Bioengineering, EarlyView.
Development of a novel synbiotic microcapsule and its impact on gut microbiota. ABSTRACT As a new type of prebiotic, the Maillard reaction products of protein ‐ oligosaccharide conjugates have emerged as a promising material for probiotic encapsulation and improve host health.
Hongxing Zhang, Yue Shen, Wanting Huang, Xinyi Fang, Yanlin Wang, Xingyuan Ma, Wenyun Zheng   +6 more
wiley   +1 more source

Screening and Validation of Reference Genes for Normalization of qRT-PCR in Rice BLB Pathogen <i>Xanthomonas oryzae</i> pv. <i>oryzae</i> Under Tetramycin Stress. [PDF]

Genes (Basel)
Fang F, Miao X, Mou T, Wang Z, Guo Y, Yang Y, Gao S, Wang Z, Xu C, Yang J.   +9 more
europepmc   +1 more source

Microbiota‐Dependent Longevity Effects of Aronia Berry (Aronia melanocarpa) in Drosophila melanogaster

Food Frontiers, EarlyView.
Aronia berry extract extends lifespan in Drosophila melanogaster by modulating commensal microbes, reducing oxidative stress, and activating the immune system via the Toll pathway. Its longevity effects are dependent on gut microbiota, highlighting the interplay between polyphenols, microbes, and aging.
Ji‐Hyeon Lee, Hye‐Yeon Lee, Jang‐Cheon Cho, Alexey Moskalev, Kyung‐Jin Min   +4 more
wiley   +1 more source

Targeted removal of the 16S rRNA anti-Shine-Dalgarno sequence by a Mycobacterium tuberculosis MazF toxin. [PDF]

J Biol Chem
Sherrier TW, Barth VC, Schifano JM, Greendyk JR, Woychik NA.   +4 more
europepmc   +1 more source

Postbiotic from Lactobacillus acidophilus Inhibits Ferroptosis in Intestinal Stem Cells via Microbiota–AhR Axis to Mitigate Colitis

Food Frontiers, EarlyView.
Lacidophilin tablets alleviate colitis by regulating gut microbiota balance and maintaining intestinal barrier integrity. ABSTRACT Inflammatory bowel disease (IBD) is a chronic, progressive intestinal disorder. Dysbiosis of the gut microbiota is strongly implicated in the onset and progression of IBD.
Denglong Sun, Chenxuan Wang, Qigui Fan, Yang Zhan, Xiaoying Cheng, Jingwen Zhang, Qinxin Wang, Yingmeng Li, Qiong Li, Yanxia Xiong, Wenjun Liu   +10 more
wiley   +1 more source

Endoplasmic Reticulum Stress Amplifies Cytokine Responses in Astrocytes via a PERK/eIF2α/JAK1 Signaling Axis

Glia, EarlyView.
ER stress amplifies TNF‐α, OSM, and IL‐1β responses in astrocytes. PERK and JAK1 signaling are required for the synergistic interaction between ER stress and inflammatory cytokines. Translational suppression attenuates the synthesis of the negative feedback regulators IκBα and SOCS3.
Anirudhya Lahiri, Savannah G. Sims, Jessica A. Herstine, Alicia Meyer, Micah J. Marshall, Ishrat Jahan, Subhodip Adhicary, Allison M. Bradbury, Gordon P. Meares   +8 more
wiley   +1 more source

Evolution and characteristics of tetracycline resistance in <i>Mycoplasma pneumoniae</i>. [PDF]

Microbiol Spectr
Xie P, Liu J, Feng Y, Zhao T, Niu W, Fang Y, Zhang X, Zhao X, Wang F, Yuan X.   +9 more
europepmc   +1 more source

Transcriptional Regulation of Microglial Metabolic and Activation States by P2RY12

Glia, EarlyView.
Transcriptionally, P2RY12‐deficient microglia show heightened metabolic activity, iron handling, and oxidative stress at baseline. Upon LPS challenge, impaired glutathione antioxidant responses suggest increased vulnerability to ferroptosis. ABSTRACT Microglia are the resident immune cells of the CNS.
Aida Oryza Lopez‐Ortiz, Madison Doceti, JaQuinta Thomas, Abigayle Duffy, Morgan Coburn, Akhabue K. Okojie, Audrey Lee, Elizabeth Aidita Sou, Alban Gaultier, Ukpong B. Eyo   +9 more
wiley   +1 more source

Differential decay of multiple environmental nucleic acid components. [PDF]

Sci Rep
Brandão-Dias PF, Shaffer M, Guri G, Parsons KM, Kelly RP, Allan EA.   +5 more
europepmc   +1 more source