Results 241 to 250 of about 487,536 (292)

Severity of effect considerations regarding the use of mutation as a toxicological endpoint for risk assessment: A report from the 8th International Workshop on Genotoxicity Testing (IWGT)

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Exposure levels without appreciable human health risk may be determined by dividing a point of departure on a dose–response curve (e.g., benchmark dose) by a composite adjustment factor (AF). An “effect severity” AF (ESAF) is employed in some regulatory contexts.
Barbara L. Parsons, Marc A. Beal, Kerry L. Dearfield, George R. Douglas, Min Gi, B. Bhaskar Gollapudi, Robert H. Heflich, Katsuyoshi Horibata, Michelle Kenyon, Alexandra S. Long, David P. Lovell, Anthony M. Lynch, Meagan B. Myers, Stefan Pfuhler, Alisa Vespa, Andreas Zeller, George E. Johnson, Paul A. White   +17 more
wiley   +1 more source

rRNA loss induced by rifampicin addition in Escherichia coli reflects extraction artifacts rather than in vivo degradation. [PDF]

Sci Rep
Burck M, Nouaille S, Carpousis AJ, Cocaign-Bousquet M, Girbal L.   +4 more
europepmc   +1 more source

Biochemical characteristics and applications of microalga Chlorella sorokiniana KNUA228 isolated from Ulleungdo

Environmental Progress &Sustainable Energy, EarlyView.
Abstract The increasing environmental and health challenges posed by fossil fuel dependency necessitate the exploration of renewable bioresources. Chlorella sorokiniana KNUA228, a microalga isolated from Ulleungdo, Republic of Korea, was investigated to evaluate its biotechnological potential. Molecular analyses confirmed its identity as C. sorokiniana,
Jin‐Won Lee, Jeong‐Mi Do, Ho‐Seong Suh, Yu‐Hee Seo, Su‐Bin Park, Ho‐Sung Yoon   +5 more
wiley   +1 more source

Yersinia pseudotuberculosis growth arrest during type-III secretion system expression is associated with altered ribosomal protein expression and decreased gentamicin susceptibility. [PDF]

PLoS Pathog
Greene J, Cotten KL, Snyder RA, Huiszoon RC, Chu S, Braza RED, Chapin AA, Stine JM, Bentley WE, Ghodssi R, Davis KM.   +10 more
europepmc   +1 more source

Development of a Zebrafish Embryo‐Based Test System for Thyroid Hormone System Disruption: 3Rs in Ecotoxicological Research

Environmental Toxicology and Chemistry, EarlyView.
Abstract There is increasing concern regarding pollutants disrupting the vertebrate thyroid hormone (TH) system, which is crucial for development. Thus, identification of TH system–disrupting chemicals (THSDCs) is an important requirement in the Organisation for Economic Co‐operation and Development (OECD) testing framework.
Lisa Gölz, Melanie Blanc‐Legendre, Maximilian Rinderknecht, Laura Behnstedt, Sara Coordes, Luisa Reger, Sacha Sire, Xavier Cousin, Thomas Braunbeck, Lisa Baumann   +9 more
wiley   +1 more source

Extracellular Vesicle‐Based mRNA Therapeutics and Vaccines

Exploration, EarlyView.
This review provides a comprehensive analysis of recent advancements in extracellular vesicle (EV)‐based messenger RNA (mRNA) applications for therapeutics and vaccines. It systematically outlines strategies for mRNA encapsulation within EVs and elucidates the challenges associated with this technology, offering insights into future research directions
Qi Li, Haonan Xing, Abid Naeem, Kaiyue Zhang, Aiping Zheng, Yuanyu Huang, Mei Lu   +6 more
wiley   +1 more source

Transcriptome-Proteome Profiling in <i>Burkholderia thailandensis</i> during the Transition from Exponential to Stationary Phase. [PDF]

J Proteome Res
Al-Tohamy A, Donnarumma F, Grove A.
europepmc   +1 more source

A rapid, simple, and economical method for the isolation of ribosomes and translational machinery for structural and functional studies. [PDF]

Nat Commun
Erath J, Kemper D, Mugo E, Jacoby A, Valenzuela E, Jungers CF, Beatty WL, Hashem Y, Jovanovic M, Djuranovic S, Pavlovic Djuranovic S.   +10 more
europepmc   +1 more source

Circular RNA Profiling Identifies <i>circ5078</i> as a <i>BMPR2</i>-Derived Regulator of Endothelial Proliferation and Stress Responses. [PDF]

Arterioscler Thromb Vasc Biol
VandenBroek MM, Sharp MC, Thompson P, Fagbola E, Quilty D, Mewburn JD, Theilmann AL, Dunham-Snary KJ, Hemnes AR, Cogan JD, Austin ED, Hamid R, Archer SL, Renwick N, Ormiston ML.   +14 more
europepmc   +1 more source