Results 211 to 220 of about 169,665 (258)

The return of metabolism: biochemistry and physiology of glycolysis

Biological Reviews, Volume 101, Issue 2, Page 751-803, April 2026.
ABSTRACT Glycolysis is a fundamental metabolic pathway central to the bioenergetics and physiology of virtually all living organisms. In this comprehensive review, we explore the intricate biochemical principles and evolutionary origins of glycolytic pathways, from the classical Embden–Meyerhof–Parnas (EMP) pathway in humans to various prokaryotic and ...
Nana‐Maria Grüning, Federica Agostini, Camila Caldana, Johannes Hartl, Matthias Heinemann, Markus A. Keller, Jan Lukas Krüsemann, Costanza Lamperti, Carole L. Linster, Steffen N. Lindner, Julia Muenzner, Jens Nielsen, Zoran Nikoloski, Bettina Siebers, Jacky L. Snoep, Hezi Tenenboim, Bas Teusink, Spencer J. Williams, Mirjam M. C. Wamelink, Markus Ralser   +19 more
wiley   +1 more source

RNA-Based Therapies for Inherited Metabolic Disorders. [PDF]

J Inherit Metab Dis
Vootukuri RS, Gurung S, Ghosh R, Mills PB, Baruteau J, Zhou H.   +5 more
europepmc   +1 more source

An Autopsy Case With Fragile X‐Associated Tremor/Ataxia Syndrome Presenting Intranuclear Inclusion Bodies Mainly in the Limbic System

Neuropathology, Volume 46, Issue 2, April 2026.
ABSTRACT Fragile X‐associated tremor/ataxia syndrome (FXTAS) is a neurodegenerative disorder characterized by a late onset and slow progression caused by a premutation (55–200 CGG repeat) in the fragile X mental retardation (FMR1) gene. Here, we report the case of a Japanese patient with FXTAS which is the first case autopsied in Japan. The patient was
Ayako Shioya, Kazuhiro Ishii, Taiki Sato, Masayuki Noguchi, Akira Tamaoka, Yuko Saito   +5 more
wiley   +1 more source

ESAT-6 Modulates Macrophage Apoptosis in Mycobacterium Tuberculosis via lncNEAT1/miR-125b-5p/TNF-α Pathway. [PDF]

Infect Drug Resist
Abudureheman Z, Gong H, Axirejiang T, Xu J, Abuduwake A, Alimu A, Mamuti M, Zheng A, Li L.   +8 more
europepmc   +1 more source

Multifaceted roles of BBX transcription factors: impacts on key agronomical traits and environmental resilience

New Phytologist, Volume 250, Issue 2, Page 762-787, April 2026.
Summary B‐box (BBX) proteins were initially characterized as transcription factors connecting light signaling to the regulation of flowering time and seedling photomorphogenesis. However, over the last decade, increasing evidence has shown that they integrate light and hormone signaling, modulating multiple physiological processes during plant life. In
Bruno Silvestre Lira, Juliene Moreira, Luciano Freschi, Magdalena Rossi   +3 more
wiley   +1 more source

RNA-based therapies for neurodevelopmental disorders: innovative tools for molecular correction. [PDF]

Front Mol Biosci
Drongitis D, Verrillo L, de Bellis A, Miano MG.   +3 more
europepmc   +1 more source

A DNA‐Based Binding Assay for the m6A‐RNA Reader Proteins

ChemBioChem, Volume 27, Issue 6, 27 March 2026.
We report the structure of the m6A‐RNA reader YTHDC2 in the complex with single‐stranded DNA. We provide evidence that the readers exhibit slightly stronger affinity for 6mA‐modified DNA than RNA. Thus, we developed an FP binding assay that uses single‐stranded DNA as probe.
Rajiv Kumar Bedi, Amedeo Caflisch
wiley   +1 more source

Application of Antisense Oligonucleotides as an Alternative Approach for Gene Expression Control and Functional Studies. [PDF]

Int J Mol Sci
Szukowska A, Żuk M, Sztompke J, Bednarz B, Kaźmierczak U.   +4 more
europepmc   +1 more source

Targeting Expanded CUG and CTG Repeats as a Therapeutic Approach for Myotonic Dystrophy Type 1 (DM1)

ChemMedChem, Volume 21, Issue 5, 13 March 2026.
DM1 is an RNA gain‐of‐function disease caused by CTG repeat expansion, producing toxic r(CUG)exp RNA that sequesters MBNL1 and impairs splicing. This review covers the field of CUG and CTG ligands identified or rationally designed as DM1 drug candidates, highlighting their molecular design, RNA‐ or DNA‐binding modes, in vitro affinities and ...
Camille Richagneux, Anton Granzhan
wiley   +1 more source

<i>Salvia miltiorrhiza</i>-derived microRNA58 inhibits tumor growth by targeting Krüppel-like factor 3 in human endothelial cells. [PDF]

Transl Cancer Res
Qin Y, Zhao M, Zhang J, Pei Y, Suo S, Wu M, Shi Y, Wu F, Shen Z, Li H, Zhang H, Zhang L.   +11 more
europepmc   +1 more source