Results 131 to 140 of about 538,895 (285)
On the conformation of transfer RNA. [PDF]
Proceedings of the National Academy of Sciences, 1968 F, Cramer +4 more
openaire +3 more sources
The Conformation of Transfer RNA
Kobunshi, 1972 一定の塩基配列で規定される転移リボ核酸(tRNA)は鎖内部での特異的塩基対形成によってクローバー葉形の二次構造をとる。三次元的にはクローバー葉構造が折りたたまれて高次構造を形成するが,その存在は主として熱変性過程の研究から明らかになった。t RNAのコンホメーションの安定化には陽イオン,とりわけ二価金属イオンが大きな効果を示す。Mg++,Mn++,Co++などはtRNAに約20～30個特異的に結合し,その会合定数は103～104の大きさである。ある種のtRNAには生物活性形と変性形が見出され,相互変換には二価イオンが決定的な役割を果す。活性形は約2～3個の二価イオン部位をよけいにもち,変換にはリン酸基の中和を伴うコンホメーション変化が起こると考えられる ...
openaire +3 more sources
Molecular Oncology, EarlyView.B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez +17 more
wiley +1 more source
Trans-kingdom small RNA transfer during host-pathogen interactions: The case of P. falciparum and erythrocytes. [PDF]
RNA Biol, 2017 Walzer KA, Chi JT.
europepmc +1 more source
FEBS Open Bio, EarlyView.FAM136A depletion upregulated ROS production, reduced mitochondrial membrane potential (ΔΨ) and ATP production, and upregulated expression of PCK1, PCK2, HMGCS1, and HMGCS2. The expression of both TOMM22 and TOMM20 was also upregulated. FAM136A depletion reduced HCCS that produce holocytochrome c by combining heme to apocytochrome c, and reduced the ...
Yushi Otsuka, Masato Yano
wiley +1 more source
Inflammation triggers RNA transfer from blood cells to brain neurons. [PDF]
PLoS Biol, 2014 Robinson R.
europepmc +1 more source
On an RNA-membrane protogenome [PDF]
arXivSelected ribonucleotide sequences bind well to zwitterionic phospholipid bilayer membranes, though randomized RNAs do not. There are no evident repeated sequences in selected membrane binding RNAs. This implies small and varied motifs responsible for membrane affinity. Such subsequences have been partially defined. Bound RNAs require divalents like Mg2+
arxiv
FEBS Open Bio, EarlyView.Osimertinib reduces angiogenesis and PDL1 expression in in ovo tumors, transforming them into ‘cold tumors’ with lower immune activity. Anatomopathological and transcriptomic analyses highlight its therapeutic impact on tumor biology. This study underscores osimertinib's potential to reshape the tumor microenvironment and provides insights into its ...
David Barthélémy +14 more
wiley +1 more source
A potential tumor suppressor role of PLK2 in glioblastoma
FEBS Open Bio, EarlyView.PLK2 was consistently downregulated in GBM tissues. Overexpression of PLK2 in GBM cell lines U87MG and U251 reduced their tumorigenic potential and enhanced cell cycle arrest and apoptosis. Suggesting that PLK2 overexpression could potentially be leveraged as a therapeutic strategy to inhibit tumor progression and enhance apoptosis, providing new ...
Xiangping Xia +5 more
wiley +1 more source
Identification of inhibitors of the Salmonella FraB deglycase, a drug target
FEBS Open Bio, EarlyView.A high‐throughput screen was used to identify inhibitors of Salmonella FraB, a drug target. Characterization of top hits (identified after an additional counter screen) revealed that some triazolidines, thiadiazolidines, and triazolothiadiazoles are mixed‐type inhibitors of FraB.
Jamison D. Law +6 more
wiley +1 more source