Results 151 to 160 of about 4,960,505 (304)

The E3 ubiquitin ligase, RNF219, suppresses CNOT6L expression to exhibit antiproliferative activity

FEBS Open Bio, EarlyView.
We identified RNF219 as a CCR4‐NOT complex‐interacting E3 ubiquitin ligase that targets the CCR4‐NOT subunit CNOT6L for ubiquitination. RNF219 directly binds to the DUF3819 domain of CNOT1 through its putative α‐helix spanning amino acids 521–542. Our findings also suggest that antiproliferative activity of RNF219 is at least partially mediated by ...
Shou Soeda, Melissa Montrose, Akinori Takahashi, Risa Ishida, Sandrine Burriel, Nao Ohmine, Tohru Natsume, Shungo Adachi, Minsoo Kim, Tadashi Yamamoto   +9 more
wiley   +1 more source

Characterization of WAC interactions with R2TP and TTT chaperone complexes linking glucose and glutamine availability to mTORC1 activity

FEBS Open Bio, EarlyView.
TTT and R2TP chaperone complexes are required for the assembly and activation of mTORC1. WAC directly interacts with components of TTT, R2TP, and mTORC1, and these interactions are affected by the availability of glucose and glutamine, correlating with changes in mTORC1 activity.
Sofía Cabezudo, Natalia Cuervo, Carmen García‐Martín, Andrés López‐Perrote, Clara Reglero, Adrián Maqueda‐Real, Ana González‐Corpas, Marina Serna, Diego Megías, Alejo Efeyan, Solip Park, Oscar Llorca   +11 more
wiley   +1 more source

Comparative analysis of the mitogenomes of multiple species of Fagaceae, with special focus on Quercus gilva. [PDF]

BMC Plant Biol
Li Y, Zheng SS, Kozlowski G, Song YG.
europepmc   +1 more source

Polydatin ameliorates ovalbumin‐induced asthma in a rat model through NCOA4‐mediated ferroautophagy and ferroptosis pathway

FEBS Open Bio, EarlyView.
In this research, a rat model of asthma was created using OVA, and polydatin served as an intervention. By inhibiting ferroautophagy mediated by NCOA4 and averting ferroptosis, polydatin has been demonstrated to reduce asthma. This work presents new ideas for investigating the mechanism of polydatin's ability to alleviate asthma, in addition to ...
Wei Li, Yuwei Tang, Wenkang Liu, Fang Fang, Jiepeng Wang, Chaoyi Fang   +5 more
wiley   +1 more source

Mechanistic insights into direct DNA and RNA strand transfer and dynamic protein exchange of SSB and RPA. [PDF]

Nucleic Acids Res
Paul T, Lee IR, Pangeni S, Rashid F, Yang O, Antony E, Berger JM, Myong S, Ha T.   +8 more
europepmc   +1 more source

Biogenesis and Function of Transfer RNA-Related Fragments (tRFs).

TIBS -Trends in Biochemical Sciences. Regular ed, 2016
Pankaj Kumar, Canan Kuscu, Anindya Dutta
semanticscholar   +1 more source

Osmotic pressure‐induced calcium response states

FEBS Open Bio, EarlyView.
Acute hypotonic stress triggers distinct calcium response patterns in HEK293T cells. These signals originate from the endoplasmic reticulum via RyR2 and propagate to neighboring cells through gap junctions. This result highlights a novel calcium‐dependent mechanism underlying the intracellular and intercellular response to osmotic pressure.
Zidan Gao, Keiji Naruse, Masatoshi Morimatsu   +2 more
wiley   +1 more source

Decoding the complete mitochondrial genome of Hydrangea chinensis maxim.: insights into genomic recombination, gene transfer, and RNA editing dynamics. [PDF]

BMC Plant Biol
Ye K, Qin J, Yonghong H.
europepmc   +1 more source

Directly visualized glioblastoma-derived extracellular vesicles transfer RNA to microglia/macrophages in the brain.

Neuro-Oncology, 2016
K. E. van der Vos, E. Abels, Xuan Zhang, C. Lai, Esteban Carrizosa, Derek H. Oakley, Shilpa Prabhakar, Osama Mardini, Matheus H W Crommentuijn, J. Skog, Anna M. Krichevsky, A. Stemmer-Rachamimov, T. Mempel, J. El Khoury, S. Hickman, X. Breakefield   +15 more
semanticscholar   +1 more source

Downregulation of sST2, a decoy receptor for interleukin‐33, enhances subcutaneous tumor growth in murine pancreatic cancer cells

FEBS Open Bio, EarlyView.
Subcutaneous implantation of murine Panc02 pancreatic cancer cells depleted of sST2, a soluble decoy receptor for the proinflammatory interleukin‐33 (IL‐33), leads to a decreased number of GLUT4‐positive cancer‐associated adipocytes, reduced levels of the anti‐inflammatory molecule adiponectin, increased phosphorylation of IκBα, elevated Cxcl3 ...
Miho Akimoto, Nobuko Koshikawa, Takao Morinaga, Mimi Tamamori‐Adachi, Atsushi Takatori, Keizo Takenaga   +5 more
wiley   +1 more source