Results 151 to 160 of about 1,721,225 (270)

A Molecular Grammar Governing the Driving Forces for Phase Separation of Prion-like RNA Binding Proteins

Cell, 2018
Jie Wang, Jeong-Mo Choi, A. Holehouse, Hyun O Lee, Xiaojie Zhang, Marcus Jahnel, Shovamayee Maharana, Régis P. Lemaitre, Andrei Pozniakovsky, D. Drechsel, I. Poser, R. Pappu, S. Alberti, A. Hyman   +13 more
semanticscholar   +1 more source

The structure of the RNA binding site of ribosomal proteins S8 and S15.

, 1979
Rachel Müller, R.A. Garrett, Harry F. Noller   +2 more
openalex   +1 more source

Landscape of BRAF transcript variants in human cancer

Molecular Oncology, EarlyView.
We investigate the annotation of BRAF variants, focusing on protein‐coding BRAF‐220 (formerly BRAF‐reference) and BRAF‐204 (BRAF‐X1). The IsoWorm pipeline allows us to quantify these variants in human cancer, starting from RNA‐sequencing data. BRAF‐204 is more abundant than BRAF‐220 and impacts patient survival.
Maurizio S. Podda, Danilo Tatoni, Gianluca Mattei, Alberto Magi, Romina D'Aurizio, Laura Poliseno   +5 more
wiley   +1 more source

Loss of proton‐sensing GPR4 reduces tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
G protein‐coupled receptor 4 (GPR4) is a pH‐sensing receptor activated by acidic pH. GPR4 expression is increased in patients with inflammatory bowel disease who are at high risk of developing colorectal cancer. In mouse models, loss of GPR4 attenuated tumor progression. This correlated with increased IL2 and natural killer cell activity.
Leonie Perren, Moana Busch, Pedro A. Ruiz, Ermanno Malagola, Valeria Baumeler, Federica Foti, Adelina Gross, Tobias Grütter, Hendrik Edel, Cordelia Schuler, Kristina Handler, Glenn De Lange, Isabelle C. Arnold, Cheryl de Vallière, Klaus Seuwen, Martin Hausmann, Gerhard Rogler   +16 more
wiley   +1 more source

The Evolutionarily-conserved Polyadenosine RNA Binding Protein, Nab2, Cooperates with Splicing Machinery to Regulate the Fate of pre-mRNA [PDF]

, 2016
Numerous RNA binding proteins are deposited onto an mRNA transcript to modulate post-transcriptional processing events ensuring proper mRNA maturation. Defining the interplay between RNA binding proteins that couple mRNA biogenesis events is crucial for ...
Bellur, Deepti L., Bergkessel, Megan, Corbett, Anita H., Deng, Qiudong, Duong, Duc, Fasken, Milo B., Guthrie, Christine, Morris, Kevin J., Seyfried, Nicholas T., Soucek, Sharon, Staley, Jonathan P., Zeng, Yi   +11 more
core   +1 more source

TRPM8 levels determine tumor vulnerability to channel agonists

Molecular Oncology, EarlyView.
TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo, Francesco Giuseppe Carbone, Kristi Buzo, Nicole Annesi, Sacha Genovesi, Annalisa Lorenzato, Karen Widmann, Michela Libergoli, Elisa Marmocchi, Giovanni Bertalot, Alberto Brolese, Mauro Giulio Papotti, Luca Molinaro, Orazio Caffo, Mattia Barbareschi, Alberto Bardelli, Alessandro Romanel, Sabrina Arena, Andrea Lunardi   +18 more
wiley   +1 more source

RNA buffers the phase separation behavior of prion-like RNA binding proteins

Science, 2018
Shovamayee Maharana, Jie Wang, D. Papadopoulos, Doris Richter, A. Pozniakovsky, I. Poser, M. Bickle, Sandra Rizk, Jordina Guillén-Boixet, Titus M. Franzmann, Marcus Jahnel, Lara Marrone, Young‐Tae Chang, J. Sterneckert, P. Tomančák, A. Hyman, S. Alberti   +16 more
semanticscholar   +1 more source

The anticancer effect of the HDAC inhibitor belinostat is enhanced by inhibitors of Bcl‐xL or Mcl‐1 in ovarian cancer

Molecular Oncology, EarlyView.
The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine, Sterenn Guillemot, Louis‐Bastien Weiswald, Romane Florent, Edwige Abeilard, Florence Giffard, Emilie Brotin, Mélanie Briand, Enora Dolivet, Laurent Poulain, Marie Villedieu   +10 more
wiley   +1 more source

Formation and Maturation of Phase-Separated Liquid Droplets by RNA-Binding Proteins.

Molecules and Cells, 2015
Yuan Lin, David S. W. Protter, M. Rosen, R. Parker   +3 more
semanticscholar   +1 more source

RNA binding proteins of the large subunit of bovine mitochondrial ribosomes [PDF]

, 1988
Mieczyslaw A. Piatyszek, Nancy D. Denslow, William J. O’Brien   +2 more
openalex   +1 more source