Results 201 to 210 of about 208,041 (335)

Cell-Associated HIV-1 DNA and RNA Decay Dynamics During Early Combination Antiretroviral Therapy in HIV-1-Infected Infants [PDF]

, 2015
Priyanka Uprety, Ellen G. Chadwick, Kaitlin Rainwater‐Lovett, Carrie Ziemniak, Katherine Luzuriaga, Edmund V. Capparelli, Gayane Yenokyan, Deborah Persaud   +7 more
openalex   +1 more source

HIGD1A Alleviates Oxidative Stress Related Ovarian Hypofunction by Enhancing Granulosa Cell Functions via NF‐κB/SOD2 Signaling Pathway

Advanced Science, EarlyView.
HIGD1A maintains redox homeostasis in granulosa cells by modulating SOD2‐mediated dismutation of superoxide into H2O2, which is cleared by CAT and GPX enzymes. However, reduced HIGD1A activates the NF‐κB pathway and upregulates SOD2, leading to intracellular H2O2 accumulation due to impaired clearance.
Huiying Li, Siying Cai, Hongbei Mu, Tianli Chang, Xiaofei Wang, Tianyu Tang, Tengyun Dong, Yu Zhang, Ling Zhang, Huaibiao Li, Liquan Zhou, Wenpei Xiang   +11 more
wiley   +1 more source

Dual agonistic and antagonistic roles of ZC3H18 provide for co-activation of distinct nuclear RNA decay pathways.

Cell Rep, 2023
Polák P, Garland W, Rathore O, Schmid M, Salerno-Kochan A, Jakobsen L, Gockert M, Gerlach P, Silla T, Andersen JS, Conti E, Jensen TH.   +11 more
europepmc   +1 more source

m6A‐Modified circRAPGEF1 Interaction with IGF2BP3 Promotes Hepatocellular Carcinoma Progression via Reprogramming Aspartate Metabolism

Advanced Science, EarlyView.
In hepatocellular carcinoma (HCC), the m6A‐modified circRAPGEF1 destabilizes ASS1 mRNA via competitive binding to IGF2BP3, driving aspartate metabolic reprogramming in liver cancer stem cells (LCSCs). This cascade enhances stemness properties and reduces sorafenib sensitivity in LCSCs, thereby identifying circRAPGEF1 as a promising therapeutic target ...
Juanyi Shi, Sintim Mui, Yongcong Yan, Shaomin Liu, Kai Wen, Chuanchao He, Huoming Li, Hao Liao, Meng Tao, Jiahua Wen, Weidong Wang, Xiaoding Xu, Zhenyu Zhou, Zhiyu Xiao   +13 more
wiley   +1 more source

Minding the message: tactics controlling RNA decay, modification, and translation in virus-infected cells. [PDF]

Genes Dev, 2022
Burgess HM, Vink EI, Mohr I.
europepmc   +1 more source

A Systematic Computational Framework for Practical Identifiability Analysis in Mathematical Models Arising from Biology

Advanced Science, EarlyView.
A systematic computational framework is developed for practical identifiability analysis in biological models. The framework establishes a rigorous definition, introduces efficient coordinate‐based identifiability metrics, and proposes novel regularization strategies.
Shun Wang, Wenrui Hao
wiley   +1 more source

Transcriptional explorations of CAPN3 identify novel splicing mutations, a large‐sized genomic deletion and evidence for messenger RNA decay

, 2007
Martin Krahn, Christophe Pécheux, Françoise Chapon, Christophe Béroud, Valérie Drouin‐Garraud, Pascal Laforêt, N. Romero, I. Pénisson-Besnier, Rafaëlle Bernard, J. Andoni Urtizberea, France Leturcq, Nicolas Lévy   +11 more
openalex   +2 more sources

RNA decay systems enhance reciprocal switching of sense and antisense transcripts in response to glucose starvation [PDF]

, 2016
Atsuko Miki, Josephine Galipon, Satoshi Sawai, Toshifumi Inada, Kunihiro Ohta   +4 more
openalex   +1 more source

Neoeriocitrin Targeting Beclin1 Deubiquitination and Autophagy in Osteogenic Differentiation of Human Dental Pulp Stem Cells

Advanced Science, EarlyView.
Neoeriocitrin enhances osteogenesis in hDPSCs and bone regeneration by targeting Beclin1 to inhibit ubiquitination‐mediated degradation, thereby stabilizing Beclin1 and increasing its protein abundance to activate autophagy. Abstract Human dental pulp stem cells (hDPSCs) are dental‐derived mesenchymal stem cells with robust multipotent differentiation ...
Yu Wu, Haotian Liu, Qunyi Wang, Ting Zhang, Rixin Chen, Qiao Yuan, Xin Tong, Wenrong Yang, Yin Xiao, Fuhua Yan   +9 more
wiley   +1 more source

Cell type- and factor-specific nonsense-mediated RNA decay. [PDF]

Nucleic Acids Res
Tan K, Sebat J, Wilkinson MF.
europepmc   +1 more source