Results 211 to 220 of about 1,912,865 (328)

Supplementary figures and legends from Nonsense-Mediated RNA Decay Is a Unique Vulnerability of Cancer Cells Harboring <i>SF3B1</i> or <i>U2AF1</i> Mutations

, 2023
Abigael Cheruiyot, Shan Li, Sridhar Nonavinkere Srivatsan, Tanzir Ahmed, Yuhao Chen, Delphine S. Lemacon, Ying Li, Zheng Yang, Brian A. Wadugu, Wayne A. Warner, Shondra M. Pruett‐Miller, Esther A. Obeng, Daniel C. Link, Dalin He, Fei Xiao, Xiaowei Wang, Julie M. Bailis, Matthew J. Walter, Zhongsheng You   +18 more
openalex   +1 more source

DualPG‐DTA: A Large Language Model‐Powered Graph Neural Network Framework for Enhanced Drug‐Target Affinity Prediction and Discovery of Novel CDK9 Inhibitors Exhibiting in Vivo Anti‐Leukemia Activity

Advanced Science, EarlyView.
This study introduces DualPG‐DTA, a framework integrating two pre‐trained models to generate molecular and protein representations. It constructs dual graphs processed by specialized neural networks with dynamic attention for feature fusion, achieving superior benchmark performance.
Yihao Chen, Jindi Huang, Cong Liu, Shipeng Zhang, Xinze Li, Zhang Zhang, Tie‐Gen Chen, Ling Wang   +7 more
wiley   +1 more source

Potyviruses recruit host eIF4A3 to block m6A-mediated RNA decay by steric hindrance of viral RNA methylation in plants. [PDF]

Nucleic Acids Res
Peng D, Dong L, Wang P, Zang L, Xie J, Wang H, Li X, Fan Z, Zhou T, Du K.   +9 more
europepmc   +1 more source

RNA 5-Methylcytosine Facilitates the Maternal-to-Zygotic Transition by Preventing Maternal mRNA Decay [PDF]

, 2019
Ying Yang, Lu Wang, Xiao Han, Wenlan Yang, Mengmeng Zhang, Haili Ma, Baofa Sun, Ang Li, Jun Xia, Jing Chen, Jian Heng, Baixing Wu, Yusheng Chen, Jiawei Xu, Xin Yang, Huan Yao, Jiawei Sun, Cong Lyu, Hailin Wang, Ying Huang, Yingpu Sun, Yongliang Zhao, Anming Meng, Jinbiao Ma, Feng Liu, Yun‐Gui Yang   +25 more
openalex   +1 more source

CircTspan3 Promotes Cartilage Development Through ANNEXIN A2‐Mediated Ferroptosis and Apoptosis Inhibition and Exosome‐Mediated Paracrine Signaling

Advanced Science, EarlyView.
This study reveals that XBP1s drives production of circTspan3, a circular RNA that strengthens cartilage by boosting anabolic activity and limiting cell death. Phosphorylated ANXA2 directs circTspan3 into exosomes, enabling paracrine repair. Exosomal circTspan3 expands growth‐plate cartilage and promotes in vivo regeneration, highlighting its promise ...
Yiming Pan, Fengmei Zhang, Jiayan Zhong, Qian Gong, Nana Geng, Biao Kuang, Qiumei Lan, Miao Yi, Qiqi Zeng, Cheng Chen, Mengtian Fan, Chunliang Zhao, Deping Zeng, Yu Du, Mao Nie, Zhibiao Wang, Fengjin Guo   +16 more
wiley   +1 more source

A Method for Rapid Inducible RNA Decay. [PDF]

Methods Mol Biol
Blake LA, Watkins L, Wu B.
europepmc   +1 more source

Stress and the nonsense-mediated RNA decay pathway

Cellular and Molecular Life Sciences, 2017
Alexandra E. Goetz, M. Wilkinson
semanticscholar   +1 more source

Astrocytic PCBP1 Suppresses Ferroptosis to Restore Glutamatergic Homeostasis and Mitigate Stress‐Induced Depression in Male Mice

Advanced Science, EarlyView.
This study demonstrates that polyC‐RNA‐binding protein 1 (PCBP1) in ventral hippocampal astrocytes modulates depressive‐like behaviors by regulating glutathione peroxidase 4‐mediated ferroptosis and synaptic glutamatergic transmission. PCBP1 overexpression intervention in the chronic unpredictable mild stress model rescues behavioral deficits ...
Jinyu Zhang, Binbin Zhao, Min Jia, Yan Zhao, Ye Lu, Wenyu Xi, Ziyu Zhu, Xiaojuan Gong, Qingyan Ma, Yuan Gao, Yijie Guo, Pan Li, Feng Zhu, Shuguang Wei, Xiancang Ma, Yunpeng Wang   +15 more
wiley   +1 more source

The RNA-binding protein RBM39 scaffolds an m⁶A-dependent RNA decay complex that destabilizes Tat transcripts and restricts HIV-1 reactivation. [PDF]

PLoS Biol
Deng X, Xie S, Zhou M, Yuan Q, Wu S, Huang P, Chen M, Zeng J, Guo P, Qin J, Chen C, Liu J, Liu B, He X, Sun L, Zhang H, Li L, Pan T.   +17 more
europepmc   +1 more source

Dual agonistic and antagonistic roles of ZC3H18 provide for co-activation of distinct nuclear RNA decay pathways.

Cell Rep, 2023
Polák P, Garland W, Rathore O, Schmid M, Salerno-Kochan A, Jakobsen L, Gockert M, Gerlach P, Silla T, Andersen JS, Conti E, Jensen TH.   +11 more
europepmc   +1 more source