Results 271 to 280 of about 208,041 (335)

Specialised RNA decay fine-tunes monogenic antigen expression in African trypanosomes

Lansink LIM, Walther L, Longmore S, Jones M, Dowle A, Faria JRC.   +5 more
europepmc   +1 more source

SARS-CoV-2 Helicase might interfere with cellular nonsense-mediated RNA decay, insights from a bioinformatics study

, 2022
Akbari B, Ahmadi E, Zamir MR, Shaker MS, Noorbakhsh F.   +4 more
europepmc   +1 more source

Supplementary_Dataset1_HESO1sequences. from RNA uridylation and decay in plants

, 2018
Caroline De Almeida, Hélène Scheer, Anthony Gobert, Veronica Fileccia, Federico Martinelli, Hélène Zuber, Dominique Gagliardi   +6 more
openalex   +2 more sources

SenExo‐cCCT2 Reprograms Senescence Response and Anti‐Tumor Immunity Following FOLFIRINOX Chemotherapy in Pancreatic Ductal Adenocarcinoma

Advanced Science, EarlyView.
This study demonstrates that SenExo‐cCCT2 enables targeted delivery of cCCT2 to pancreatic cancer cells, where it disrupts IPO13‐mediated nuclear translocation of UBC9, impairing SUMOylation‐dependent DNA damage repair and inducing senescence. Senescent tumor cells secrete CXCL10 to recruit CD8⁺ T‐cells while upregulating PD‐L1.
Shuncang Zhu, Yinhao Chen, Hongyi Lin, Jinpeng Lu, Yu Pan, Ge Li, Yongding Wu, Haoxiang Zhang, Xiaoxiao Huang, Yiting Chen, Huangjing Chen, Long Jin, Min Huang, Chengyu Liao, Long Huang, Yifeng Tian, Zuwei Wang, Qiaowei Li, Shi Chen   +18 more
wiley   +1 more source

Zika virus noncoding sfRNAs sequester multiple host-derived RNA-binding proteins and modulate mRNA decay and splicing during infection

, 2019
Daniel Michalski, J. Gustavo Ontiveros, Joseph Russo, Phillida A. Charley, John R. Anderson, Adam M. Heck, Brian J. Geiss, Jeffrey Wilusz   +7 more
openalex   +1 more source

Hsa_circ_0026782 Acts as a “Molecular Break” of CREB1‐Mediated Transcription by Promoting Its Phosphorylation at Ser142 That Prevents Keloid Progression

Advanced Science, EarlyView.
Model for the role of hsa_circ_0026782/p‐CREB1 (Ser142) played in keloid. Hsa_circ_0026782 is derived from back‐splicing of ITGA7 exon 4. When hsa_circ_0026782 binds to CREB1, the exposure of the bZIP domain and dimerization of CREB1 are promoted (upper left).
Xin‐Cao Zhong, Chun‐Ye Chen, Zi‐Xuan Feng, Yong Wang, Tao Zhang, Ze‐Ming Zhuang, Zhang‐Rui Wu, Yong‐Zhong Du, Jun Chen, Xiao‐Ying Lin, Wei‐Qiang Tan   +10 more
wiley   +1 more source

Comparative Single‐Cell Transcriptomic Landscape Reveals the Regulatory Mechanisms of Lactation during Selective Breeding in Asian Water Buffalo

Advanced Science, EarlyView.
In this study, a comprehensive single‐cell transcriptome atlas of river and swamp buffalo, encompassing 12 tissues and 397,011 cells, is constructed. Differential expression analyses identify metabolic and secretory tissues and cell types that mediate the divergence of milk production.
Dongmei Dai, Jingfang Si, Li Jiang, Bo Han, Kailai Wang, Xue Wang, Shihui Yan, Yichang Yin, Wei Chen, Huaming Mao, Alfredo Pauciullo, Shang‐Tong Li, Lingzhao Fang, Yi Zhang   +13 more
wiley   +1 more source

Divergent Delivery and Expression Kinetics of Lipid and Polymeric Nanoparticles across mRNA Modalities

Advanced Science, EarlyView.
Self‐amplifying (saRNA), linear (linRNA), and circular (circRNA) mRNAs are compared under standardized conditions using lipid nanoparticles (LNPs) and pABOL polymer. saRNA achieved superior expression, while linRNA and circRNA performance varied based on untranslated region elements and delivery method.
Irafasha C. Casmil, Josh J. Friesen, Nuthan V. Bathula, Anneke Strumpel, Chia Hao Ho, Ilana Guez, Kristen Y. S. Kong, Andrew J. Varley, Shigeki J. Miyake‐Stoner, Parinaz Aliahmad, Nathaniel S. Wang, Andrew J. Geall, Anna K. Blakney   +12 more
wiley   +1 more source

Single Mitochondrion Morphology‐Function Relationship Analysis Using Fluorescent Probes and Artificial Intelligence

Advanced Science, EarlyView.
An integrated strategy combining a mitochondria‐targeted fluorescent probe set and an AI framework enables simultaneous analysis of mitochondrial morphology and function at the single organelle level. By fusing multi‐parametric features, machine learning classification accurately distinguishes individual mitochondria under hypoxia‐related conditions ...
Yang Ding, Bin Fang, Qingzhe Li, Biying Zhang, Jintao Li, Hua Bai, Nicolas H. Voelcker, Bo Peng, Xuekang Yang, Lin Li   +9 more
wiley   +1 more source