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The evolution of edited RNA transcripts
Science, 2017RNA Editing Differences occur between nucleotides encoded within DNA and the RNAs transcribed from these sequences. Such RNA editing can lead to changes in the amino acid composition of resulting proteins, and the removal of editing can have pathological consequences. Examining the occurrence of A-to-I editing in coding and noncoding RNA transcripts in
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2008
RNA editing has been observed in chloroplast transcripts from most land plants, but not from algae. In higher plant chloroplasts, C-to-U conversion occurs at around 30 specific sites in mRNAs, many of which result in amino acid alteration. Occasionally, RNA editing creates an AUG initiation codon from ACG, and a UAA termination codon from CAA.
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RNA editing has been observed in chloroplast transcripts from most land plants, but not from algae. In higher plant chloroplasts, C-to-U conversion occurs at around 30 specific sites in mRNAs, many of which result in amino acid alteration. Occasionally, RNA editing creates an AUG initiation codon from ACG, and a UAA termination codon from CAA.
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In vivo base editing rescues Hutchinson–Gilford progeria syndrome in mice
Nature, 2021Luke W Koblan+2 more
exaly
Investigating RNA editing in deep transcriptome datasets with REDItools and REDIportal
Nature Protocols, 2020Claudio Lo Giudice+3 more
semanticscholar +1 more source
RNA Editing with CRISPR Cas-13
Academia Letters, 2021Thualfeqar Almohanna
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Structural biology of CRISPR–Cas immunity and genome editing enzymes
Nature Reviews Microbiology, 2022Joy Y Wang+2 more
exaly
Programmable RNA editing by recruiting endogenous ADAR using engineered RNAs
Nature Biotechnology, 2019Liang Qu+12 more
semanticscholar +1 more source
Precise RNA editing by recruiting endogenous ADARs with antisense oligonucleotides
Nature Biotechnology, 2019T. Merkle+8 more
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