Results 281 to 290 of about 1,338,157 (346)

Exploring the Potential and Advancements of Circular RNA Therapeutics

Exploration, EarlyView.
Given the remarkable advantages in terms of stability, sustained expression profile, safety, wide range of druggable targets, scalable and cost‐effective manufacturing capabilities, circRNA is currently undergoing intensive investigation for various therapeutic applications such as vaccines, protein replacement, genetic disease treatment, gene therapy,
Lei Wang, Lianqing Wang, Chunbo Dong, Jialong Liu, Guoxin Cui, Shan Gao, Zhida Liu   +6 more
wiley   +1 more source

Emerging Target Discovery Strategies Drive the Decoding of Therapeutic Power of Natural Products and Further Drug Development: A Case Study of Celastrol

Exploration, EarlyView.
Using celastrol as a case study, this review summarizes various target discovery strategies for natural products, including chemical proteomics, protein microarray, degradation‐based protein profiling, proteome‐wide label‐free approaches, network pharmacology, target‐based drug screening, and indirect strategies.
Yanbei Tu, Guiyu Dai, Yanyan Chen, Lihua Tan, Hanqing Liu, Meiwan Chen   +5 more
wiley   +1 more source

Molecular trade-offs in RNA ligases affected the modular emergence of complex ribozymes at the origin of life

, 2017
Nisha Dhar, Marc S. Weinberg, Richard E. Michod, Pierre Durand   +3 more
openalex   +1 more source

The RNA Binding Protein Bcas2 is Required for Antibody Class Switch in Activated‐B Cells

Exploration, EarlyView.
Bcas2 recruits DHX15 and SRSF7 to form a protein complex for the splicing of CSR‐related mRNA at the 5' ss and 3' ss, generating two mature mRNA isoforms, which are ultimately translated into CSR‐related proteins. These CSR‐related proteins bind to DNA associated with antibodies, affecting the DSB repair of the relevant DNA after AID induction, thereby
Yu Chen, Siyuan Sun, Chenxu Lu, Yixuan Li, Bing Fang, Xiangfeng Tang, Xuepeng Li, Weiru Yu, Yumei Lei, Longjie Sun, Ming Zhang, Jiazeng Sun, Ping Liu, Yongting Luo, Xingwang Zhao, Jing Zhan, Libing Liu, Rong Liu, Jiaqiang Huang, Ziwei Yi, Yifei Yu, Weihan Xiao, Zheng Ding, Lei Li, Dan Su, Fazheng Ren, Changchang Cao, Ran Wang, Wenbiao Shi, Juan Chen   +29 more
wiley   +1 more source

Application of Ferulic Acid to Alleviate Chilling Injury of Banana Fruit by Regulating Redox, Phenylpropanoid, and Energy Metabolism

Food Frontiers, EarlyView.
This study investigated the effect of ferulic acid (FA) on the cold tolerance of banana fruit under 6°C‐storage for 7 days. In comparison with control, 3 mM FA treatment significantly alleviated chilling symptoms of banana fruit by enhancing phenylpropanoid metabolism and maintaining redox and energy homeostasis. ABSTRACT Banana fruit is susceptible to
Yu Hou, Min Gou, Zhengke Zhang, Lanhuan Meng, Lisha Zhu, Xiangbin Xu, Taotao Li, Yueming Jiang, Jianbo Xiao, Jiali Yang   +9 more
wiley   +1 more source

Additional file 2: of RNA-sequencing reveals altered skeletal muscle contraction, E3 ligases, autophagy, apoptosis, and chaperone expression in patients with critical illness myopathy

, 2019
Monica Llano‐Diez, Wen Fury, Haruka Okamoto, Yu Bai, Jesper Gromada, Lars Larsson   +5 more
openalex   +2 more sources

Decoding RNA–Protein Interactions: Methodological Advances and Emerging Challenges

Advanced Genetics, EarlyView.
This review provides a comprehensive comparison of RNA‐ and protein‐centric methodologies for investigating RNA–protein interactions, emphasizing their respective advantages, limitations, and suitable applications. It highlights recent technological innovations, outlines strategic method selection criteria, and addresses key challenges.
Wenkai Yi, Jian Yan
wiley   +1 more source

Three-dimensional structure model and predicted ATP interaction rewiring of a deviant RNA ligase 2. [PDF]

BMC Struct Biol, 2015
Moreira S, Noutahi E, Lamoureux G, Burger G.   +3 more
europepmc   +1 more source

Bacteriophage T4 RNA ligase 2 (gp24.1) exemplifies a family of RNA ligases found in all phylogenetic domains

Proceedings of the National Academy of Sciences of the United States of America, 2002
C. Ho, S. Shuman
semanticscholar   +1 more source

Recent Advancements in Microfluidic Biosensors for Clinical Applications

iLABMED, EarlyView.
The combination of low‐consumption microfluidic chips and high‐sensitivity biosensors enables rapid and accurate detection of complex target analytes. This integrated system holds significant potential for applications in disease diagnosis, health monitoring, and treatment management.
Haiyan Wang, Wenjuan Wu
wiley   +1 more source