Results 141 to 150 of about 1,777,446 (290)
Molecular Insights into Intracellular RNA Localization [PDF]
, 2013 Localization of mRNAs to specific destinations within a cell or an embryo is important for local control of protein synthesis. mRNA localization is well known to function in very large and polarized cells such as neurons, and to facilitate embryonic patterning during early development.
openaire +2 more sources
RNA localization during early development of the axolotl. [PDF]
Front Cell Dev Biol, 2023 Šimková K +4 more
europepmc +1 more source
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
TDP-43 directly inhibits mRNA accumulation in neurites through modulation of mRNA stability
The EMBO JournalThe subcellular localization of many mRNAs to neuronal projections allows neurons to efficiently and rapidly react to spatially restricted external cues. However, for most of these RNAs, the mechanisms that govern their localization are unknown.
Charlie Moffatt +9 more
doaj +1 more source
Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk
Molecular Oncology, EarlyView.Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley +1 more source
Condensate functionalization with microtubule motors directs their nucleation in space and allows manipulating RNA localization. [PDF]
EMBO J, 2023 Cochard A +5 more
europepmc +1 more source
Molecular Oncology, EarlyView.Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley +1 more source
The translational repressor Cup is required for germ plasm assembly and germ cell development in Drosophila. [PDF]
, 2011 RNA localization is a cellular mechanism used to localize proteins to sub-cellular domains and to control protein synthesis regionally. In oocytes, RNA localization has profound implications for development, generating asymmetric protein distributions ...
Ottone, Cristina
core +1 more source
Germ granule localization of nematode Argonaute WAGO-4 ensures fidelity in small RNA loading
The EMBO JournalGerm granules are liquid-like condensates that regulate small RNA pathways and gene expression, ensuring genome stability and fertility in animals. In C.
Stela Jelenic +8 more
doaj +1 more source
High-throughput identification of RNA localization elements in neuronal cells. [PDF]
Nucleic Acids Res, 2022 Arora A +8 more
europepmc +1 more source