Results 331 to 340 of about 2,070,961 (352)
Mechanism of RNA packaging motor.
Advances in Experimental Medicine and Biology, 2012 P4 proteins are hexameric RNA packaging ATPases of dsRNA bacteriophages of the Cystoviridae family. P4 hexamers are integral part of the inner polymerase core and play several essential roles in the virus replication cycle. P4 proteins are structurally related to the hexameric helicases and translocases of superfamily 4 (SF4) and other RecA-like ...
E. Mancini, R. Tuma
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Retroviral RNA packaging: a review.
Archives of virology. Supplementum, 1994In retroviruses, the "Gag" or core polyprotein is capable of assembling into virus particles and packaging the genomic RNA of the virus. How this protein recognizes viral RNA is not understood. Gag polyproteins contain a zinc-finger domain; mutants with changes in this domain assemble into virions, but a large fraction of these particles lack viral RNA.
A. Rein
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Packaging RNA drugs into extracellular vesicles
Nature Biomedical Engineering, 2020The therapeutic dose of small interfering RNA can be reduced by endogenously expressing and packaging the RNA into extracellular vesicles through its integration with the backbone of a highly enriched pre-microRNA.
van Eijndhoven, Monique A J +2 more
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Journal of Virology, 2022
While numerous viral genomes comprise a single genome segment, the influenza A virus possesses eight segmented genomes. Influenza A virus can benefit from having a segmented genome because the segments can reassort with other strains of the influenza virus to create new genetically distinct strains.
Sho Miyamoto +8 more
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While numerous viral genomes comprise a single genome segment, the influenza A virus possesses eight segmented genomes. Influenza A virus can benefit from having a segmented genome because the segments can reassort with other strains of the influenza virus to create new genetically distinct strains.
Sho Miyamoto +8 more
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Packaging of HCV-RNA into lentiviral vector
Biochemical and Biophysical Research Communications, 2011The advent of infectious molecular clones of Hepatitis C virus (HCV) has unlocked the understanding of HCV life cycle. However, packaging of the genomic RNA, which is crucial to generate infectious viral particles, remains poorly understood. Molecular interactions of the domain 1 (D1) of HCV Core protein and HCV RNA have been described in vitro.
Vincent Caval +4 more
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Archives of Virology, 2005
A minimal bovine leukemia virus (BLV) RNA packaging sequence (E) required for heterologous RNAs to be packaged into BLV particles was analyzed. The BLV E was inserted into a non-viral vector, pLacZ, in order to determine if packaging of the non-viral vector RNA would occur. The construct was transfected into cells chronically infected with BLV in order
Nancy A. Jewell +2 more
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A minimal bovine leukemia virus (BLV) RNA packaging sequence (E) required for heterologous RNAs to be packaged into BLV particles was analyzed. The BLV E was inserted into a non-viral vector, pLacZ, in order to determine if packaging of the non-viral vector RNA would occur. The construct was transfected into cells chronically infected with BLV in order
Nancy A. Jewell +2 more
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Packaged Heteroclite Subgenomic RNAs of PRRSV
2001Porcine reproductive and respiratory syndrome virus (PRRSV) is a member of the Arteriviridae family of the Nidovirales (Meulenberg et al, 1993b; Nelsen et al., 1999). While the complete genomes of three PRRSV strains are known (Allende et al., 1999; Meulenberg et al., 1993; Nelsen et al., 1999), main questions remains to be elucidated concerning viral ...
Kay S. Faaberg +2 more
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Structure of B77 sarcoma virus RNA: stabilization of RNA after packaging [PDF]
Journal of Virology, 1975 Extracellular maturation of Bratislava 77(B77) sarcoma virus RNA involves a stabilization of linkage between 35S subunits since the Tm of 60 to 70S RNA in the presence of 0.5 M NaCl increases from 56 to 67.5 C as the age of the virus increases. This stabilization process is strongly temperature dependent; the rate at 45 C is increased fourfold over the
P N Snyder, C M Stoltzfus
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2007
Publisher Summary This chapter focuses on the concept of human immunodeficiency virus type 1 (HIV‐1) RNA packaging. RNA encapsidation by retroviruses is a remarkable process by which the virus negotiates the trafficking of a minority species of mRNA through a particular cellular pathway to become its genome.
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Publisher Summary This chapter focuses on the concept of human immunodeficiency virus type 1 (HIV‐1) RNA packaging. RNA encapsidation by retroviruses is a remarkable process by which the virus negotiates the trafficking of a minority species of mRNA through a particular cellular pathway to become its genome.
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Retroviral RNA Packaging: Sequence Requirements and Implications [PDF]
, 1990 Unlike many animal viruses, infection by retroviruses generally does not lead to cessation of host RNA synthesis. Despite the high levels of host RNA in infected cells, the vast majority of retroviral particles contain a precise genomic complex consisting of two molecules of genomic RNA, rather than cellular or subgenomic viral mRNAs.
A. D. Miller, Maxine L. Linial
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