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The RNA Polymerase II Core Promoter [PDF]
Annual Review of Biochemistry, 2003 ▪ Abstract The events leading to transcription of eukaryotic protein-coding genes culminate in the positioning of RNA polymerase II at the correct initiation site. The core promoter, which can extend ∼35 bp upstream and/or downstream of this site, plays a central role in regulating initiation.
James T. Kadonaga, Stephen T. Smale
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The Mediator of RNA polymerase II
Chromosoma, 2005Mediator (TRAP/ARC/PC2) is a large (22-28 subunit) protein complex that binds RNA polymerase II and controls transcription from class II genes. The evolutionarily conserved core of Mediator is found in all eukaryotes. It binds RNA polymerase II and is probably critical for basal transcription but it also mediates activation and repression of ...
Michael Meisterernst +2 more
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Dephosphorylating RNA polymerase II [PDF]
Science, 2020 Transcription Transcription in metazoans requires coordination of multiple factors to control the progression of polymerases and the integrity of their RNA products. Zheng et al. identified a new dual-enzyme complex called INTAC, which is composed of protein phosphatase 2A (PP2A) core enzyme and the multisubunit RNA endonuclease Integrator.
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The RNA Polymerase II Elongation Complex
Annual Review of Biochemistry, 1995▪ Abstract Synthesis of eukaryotic mRNA by RNA polymerase II is an elaborate biochemical process that requires the concerted action of a large set of transcription factors. RNA polymerase II transcription proceeds through multiple stages designated preinitiation, initiation, and elongation.
Ali Shilatifard +2 more
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Identification of Integrator-PP2A complex (INTAC), an RNA polymerase II phosphatase
Science, 2020Dephosphorylating RNA polymerase II Transcription in metazoans requires coordination of multiple factors to control the progression of polymerases and the integrity of their RNA products. Zheng et al.
Hai Zheng +14 more
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Transcript Elongation by RNA Polymerase II
Annual Review of Biochemistry, 2010Until recently, it was generally assumed that essentially all regulation of transcription takes place via regions adjacent to the coding region of a gene—namely promoters and enhancers—and that, after recruitment to the promoter, the polymerase simply behaves like a machine, quickly “reading the gene.” However, over the past decade a revolution in ...
Selth, L., Sigurdsson, S., Svejstrup, J.
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Advances in RNA polymerase II transcription
Current Biology, 1992Multiple protein factors are necessary to mediate transcription by RNA polymerase II. Recently, a number of advances have been made in our understanding of how general transcription factors collectively modulate basal transcription in the context of different promoter environments and how this process is activated and repressed by accessory components.
Leigh Zawel, Danny Reinberg
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Regulation of RNA polymerase II transcription
Current Opinion in Cell Biology, 1993Transcription initiation plays a central role in the regulation of gene expression. Exciting developments in the last year have furthered our understanding of the interactions between general transcription factors and how these factors respond to modulators of transcription.
Alejandro Merino +2 more
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Trends in Biochemical Sciences, 1990
Eukaryotic RNA polymerase II contains two distinct structural domains: a catalytic core consisting of subunits that are homologous to other multisubunit RNA polymerases, and a unique extension of the carboxy-terminus of the largest subunit comprising tandem repeats of the seven amino acid sequence YSPTSPS. This repetitive 'tail' domain is essential for
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Eukaryotic RNA polymerase II contains two distinct structural domains: a catalytic core consisting of subunits that are homologous to other multisubunit RNA polymerases, and a unique extension of the carboxy-terminus of the largest subunit comprising tandem repeats of the seven amino acid sequence YSPTSPS. This repetitive 'tail' domain is essential for
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The Catalytic Mechanism of RNA Polymerase II
Journal of Chemical Theory and Computation, 2011Eukaryotic RNA polymerase II (RNAP II) transcribes the DNA into mRNA. The presence of two metal ions (usually Mg(2+)) and conserved aspartate residues in the active sites of all nucleic acid polymerases led to the adoption of a universal catalytic mechanism, known as the "two metal ion catalysis".
Maria J. Ramos +2 more
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