Results 91 to 100 of about 1,879,245 (305)

Statistical mechanics of secondary structures formed by random RNA sequences

, 2001
The formation of secondary structures by a random RNA sequence is studied as a model system for the sequence-structure problem omnipresent in biopolymers. Several toy energy models are introduced to allow detailed analytical and numerical studies. First,
A. K. Hartmann, A. Pagnani, A. Pagnani, B. Maier, C. Flamm, D. A. Huse, E. I. Shakhnovich, H. Isambert, I. L. Hofacker, I. Tinoco, Jr., J. L. Cardy, J. N. Onuchic, J. S. McCaskill, K. A. Dill, L.-H. Tang, M. Mitas, M. Zuker, P. G. de Gennes, P. G. Higgs, P. G. Higgs, R. Arratia, R. Bundschuh, R. Bundschuh, S. E. Korshunov, S. F. Edwards, S. J. Chen, S. M. Freier, S. R. Morgan, S. R. Morgan, T. C. Lubensky, T. Garel, T. Hwa, T. Hwa   +32 more
core   +2 more sources

Assessing long-distance RNA sequence connectivity via RNA-templated DNA–DNA ligation

eLife, 2015
Many RNAs, including pre-mRNAs and long non-coding RNAs, can be thousands of nucleotides long and undergo complex post-transcriptional processing. Multiple sites of alternative splicing within a single gene exponentially increase the number of possible ...
Christian K Roy, Sara Olson, Brenton R Graveley, Phillip D Zamore, Melissa J Moore   +4 more
doaj   +1 more source

Unlocking the potential of tumor‐derived DNA in urine for cancer detection: methodological challenges and opportunities

Molecular Oncology, EarlyView.
Urine is a rich source of biomarkers for cancer detection. Tumor‐derived material is released into the bloodstream and transported to the urine. Urine can easily be collected from individuals, allowing non‐invasive cancer detection. This review discusses the rationale behind urine‐based cancer detection and its potential for cancer diagnostics ...
Birgit M. M. Wever, Renske D. M. Steenbergen   +1 more
wiley   +1 more source

Footprints of a Singular 22-Nucleotide RNA Ring at the Origin of Life

Biology, 2020
(1) Background: Previous experimental observations and theoretical hypotheses have been providing insight into a hypothetical world where an RNA hairpin or ring may have debuted as the primary informational and functional molecule.
Jacques Demongeot, Alexandra Henrion-Caude   +1 more
doaj   +1 more source

Subpar reporting of pre‐analytical variables in RNA‐focused blood plasma studies

Molecular Oncology, EarlyView.
Pre‐analytical variables strongly influence the analysis of extracellular RNA (cell‐free RNA; exRNA) derived from blood plasma. Their reporting is essential to allow interpretation and replication of results. By evaluating 200 exRNA studies, we pinpoint a lack of reporting pre‐analytical variables associated with blood collection, plasma preparation ...
Céleste Van Der Schueren, Philippe Decruyenaere, Francisco Avila Cobos, Johanna Bult, Jill Deleu, Laudonia Lidia Dipalo, Hetty Hilde Helsmoortel, Eva Hulstaert, Annelien Morlion, Elena Ramos Varas, Kathleen Schoofs, Wim Trypsteen, Eveline Vanden Eynde, Hanne Van Droogenbroeck, Kimberly Verniers, Jo Vandesompele, Anneleen Decock   +16 more
wiley   +1 more source

Über die Sequenzanalyse an Ribonukleinsäuren

CHIMIA, 1971
Methods used for the nucleotide sequence determination of ribonucleic acids are reviewed. Special emphasis is given to a new approach to the sequence determination of bacteriophage Qß RNA using enzymatically synthesized RNA. 
Martin A. Billeter
doaj   +1 more source

Identification of functional and diverse circulating cancer‐associated fibroblasts in metastatic castration‐naïve prostate cancer patients

Molecular Oncology, EarlyView.
Cancer‐associated fibroblasts (CAFs) promote cancer growth, invasion (metastasis), and drug resistance. Here, we identified functional and diverse circulating CAFs (cCAFs) in patients with metastatic prostate cancer (mPCa). cCAFs were found in higher numbers and were functional and diverse in mPCa patients versus healthy individuals, suggesting their ...
Richell Booijink, Leon W. M. M. Terstappen, Eshwari Dathathri, Khrystany Isebia, Jaco Kraan, John Martens, Ruchi Bansal   +6 more
wiley   +1 more source

Use of RNA secondary structure for evolutionary relationships : investigating RNase P and RNase MRP : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Genetics at Massey University, New Zealand [PDF]

, 1998
Bioinformatics is applied here to examine whether RNA secondary structure data can reflect distant evolutionary relationships. This is important when there is little confidence in sequence data such as when looking at the evolution of RNase MRP (MRP ...
Collins, Lesley Joan
core  

Surfaceome: a new era in the discovery of immune evasion mechanisms of circulating tumor cells

Molecular Oncology, EarlyView.
In the era of immunotherapies, many patients either do not respond or eventually develop resistance. We propose to pave the way for proteomic analysis of surface‐expressed proteins called surfaceome, of circulating tumor cells. This approach seeks to identify immune evasion mechanisms and discover potential therapeutic targets. Circulating tumor cells (
Doryan Masmoudi, Jérome Vialaret, Christophe Hirtz, Catherine Alix‐Panabières   +3 more
wiley   +1 more source

MRM-BERT: a novel deep neural network predictor of multiple RNA modifications by fusing BERT representation and sequence features

RNA Biology
RNA modifications play crucial roles in various biological processes and diseases. Accurate prediction of RNA modification sites is essential for understanding their functions. In this study, we propose a hybrid approach that fuses a pre-trained sequence
Linshu Wang, Yuan Zhou
doaj   +1 more source