Results 121 to 130 of about 1,879,245 (305)
Molecular Oncology, EarlyView.MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin +14 more
wiley +1 more source
RiboDiffusion: Tertiary Structure-based RNA Inverse Folding with Generative Diffusion Models [PDF]
arXivRNA design shows growing applications in synthetic biology and therapeutics, driven by the crucial role of RNA in various biological processes. A fundamental challenge is to find functional RNA sequences that satisfy given structural constraints, known as the inverse folding problem.
arxiv
A contact-waiting-time metric and RNA folding rates [PDF]
arXiv, 2009 Metrics for indirectly predicting the folding rates of RNA sequences are of interest. In this letter, we introduce a simple metric of RNA structural complexity, which accounts for differences in the energetic contributions of RNA base contacts toward RNA structure formation.
arxiv
Recognition of size and sequence by an RNA replicase. [PDF]
, 1965 I Haruna, S. Spiegelman
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Molecular Oncology, EarlyView.Epithelial–mesenchymal transition (EMT) and tumor‐infiltrating lymphocytes (TILs) are associated with early breast cancer response to neoadjuvant chemotherapy (NAC). This study evaluated EMT and TIL shifts, with immunofluorescence and RNA sequencing, at diagnosis and in residual tumors as potential biomarkers associated with treatment response.
Françoise Derouane +16 more
wiley +1 more source
Multi-objective genetic algorithm for pseudoknotted RNA sequence design
Frontiers in Genetics, 2012 RNA inverse folding is a computational technology for designing RNA sequences which fold into a user-specified secondary structure. Although pseudoknots are functionally important motifs in RNA structures, less reports concerning the inverse folding of ...
Akito eTaneda
doaj +1 more source
Adverse prognosis gene expression patterns in metastatic castration‐resistant prostate cancer
Molecular Oncology, EarlyView.We aggregated a cohort of 1012 mCRPC tissue samples from 769 patients and investigated the association of gene expression‐based pathways with clinical outcomes. Loss of AR signaling, high proliferation, and a glycolytic phenotype were independently prognostic for poor outcomes, and an adverse transcriptional feature score incorporating these pathways ...
Marina N. Sharifi +26 more
wiley +1 more source
Heterogeneity of gene expression of the hemagglutinin-esterase (HE) protein of murine coronaviruses. [PDF]
, 1991 The hemagglutinin-esterase (HE) membrane glycoprotein is present only in some members of the coronavirus family, including some strains of mouse hepatitis virus (MHV). In the JHM strain of MHV, expression of the HE gene is variable and corresponds to the
Banner, LR, Lai, MM, Yokomori, K
core
RNAFlow: RNA Structure & Sequence Design via Inverse Folding-Based Flow Matching [PDF]
arXivThe growing significance of RNA engineering in diverse biological applications has spurred interest in developing AI methods for structure-based RNA design. While diffusion models have excelled in protein design, adapting them for RNA presents new challenges due to RNA's conformational flexibility and the computational cost of fine-tuning large ...
arxiv
Reactions Sequence of Leucine Activation Catalysed by Leucyl-RNA Synthetase. 2. Formation of Complexes between the Enzyme and Substrates [PDF]
, 1968 Pierre Rouget, F. Chapeville
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