Results 151 to 160 of about 1,213,585 (311)

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

A mathematical framework for human neutrophil state transitions inferred from single-cell RNA sequence data. [PDF]

Front Immunol
Wigerblad G, Carruthers J, Ray S, Finnie T, Lythe G, Pyne S, Molina-París C, Kaplan MJ.   +7 more
europepmc   +1 more source

Reverse transcription loop-mediated isothermal amplification (RT-LAMP) primer design based on Indonesia SARS-CoV-2 RNA sequence. [PDF]

J Genet Eng Biotechnol, 2023
Ibadurrahman I, Suryani, Desriani.
europepmc   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

DRFormer: A Benchmark Model for RNA Sequence Downstream Tasks. [PDF]

Genes (Basel)
Fu J, Li H, Kang Y, Zhu H, Huang T, Li Z.   +5 more
europepmc   +1 more source

Improved downstream functional analysis of single-cell RNA-sequence data using DGAN. [PDF]

Sci Rep, 2023
Pandey D, Onkara PP.
europepmc   +1 more source

Mechanism of sequence-specific pausing of bacterial RNA polymerase

, 2009
Maria L. Kireeva, Mikhail Kashlev
openalex   +1 more source

Compilation of small ribosomal sobunit RNA sequences [PDF]

, 1986
Erik Huysmans, Rupert De Wächter
openalex   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Improved cross-protection and immunity against influenza A virus in mice using a novel mRNA vaccine with optimized design of RNA sequence. [PDF]

Mol Ther Nucleic Acids
Wang T, Han R, Hao Z, Cheng X, Li J, Zhai C, Guo J, Wang D, Deng Y, Zhang L, Tan W.   +10 more
europepmc   +1 more source