Results 271 to 280 of about 293,102 (292)
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Annual Review of Genetics, 2002
▪ Abstract Although initially recognized as a handy tool to reduce gene expression, RNA silencing, triggered by double-stranded RNA molecules, is now recognized as a mechanism for cellular protection and cleansing: It defends the genome against molecular parasites such as viruses and transposons, while removing abundant but aberrant nonfunctional ...
Marcel Tijsterman +2 more
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▪ Abstract Although initially recognized as a handy tool to reduce gene expression, RNA silencing, triggered by double-stranded RNA molecules, is now recognized as a mechanism for cellular protection and cleansing: It defends the genome against molecular parasites such as viruses and transposons, while removing abundant but aberrant nonfunctional ...
Marcel Tijsterman +2 more
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Current Opinion in Biotechnology, 2000
Gene silencing through the increased degradation of mRNA appears to represent a novel cellular pathway that is functional in a broad range of organisms. Recent work has established a role for RNA silencing in host antiviral defense and transposon silencing, suggesting a potential application in plant functional genomics.
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Gene silencing through the increased degradation of mRNA appears to represent a novel cellular pathway that is functional in a broad range of organisms. Recent work has established a role for RNA silencing in host antiviral defense and transposon silencing, suggesting a potential application in plant functional genomics.
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RNA-dependent RNA polymerases in RNA silencing
Biological Chemistry, 2011Abstract RNA-dependent RNA polymerases (RdRPs) synthesize double-stranded RNAs that are processed into small RNAs and mediate gene silencing. Viral RdRPs and cellular RdRPs show little structural homology to each other. Cellular RdRPs play key roles in RNA silencing by producing complementary strands for target RNAs via Dicer-dependent and -
Yoshiko Maida, Kenkichi Masutomi
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Cellular and Molecular Life Sciences, 2003
A number of gene-silencing phenomena including co-suppression discovered in plants, quelling in fungi and RNA interference in animals have been revealed to have steps in common. All occur in the cytoplasm at a post-transcriptional level with the mRNAs of target genes degraded in a sequence-specific manner. Small non-coding RNA molecules demonstrated to
A. S. Pickford, COGONI, Carlo
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A number of gene-silencing phenomena including co-suppression discovered in plants, quelling in fungi and RNA interference in animals have been revealed to have steps in common. All occur in the cytoplasm at a post-transcriptional level with the mRNAs of target genes degraded in a sequence-specific manner. Small non-coding RNA molecules demonstrated to
A. S. Pickford, COGONI, Carlo
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In Vitro Cellular & Developmental Biology - Plant, 2005 Abstract The notion that the introduction of alien RNA into an organism can cause the silencing of endogenous genes and transgenes came to light in plants during the last decades of the 20th century. It was based on revealing virus-induced gene silencing (VIGS) and on the protection against pathogenic viruses by pre-infection with less pathogenic plant
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RNA Silencing in the Aspergilli
2007CONTENTS 13.1 Introduction 197 13.2 Experimental RNA Silencing 19813.2.1 Aspergillus fumigatus 198 13.2.2 Aspergillus fl avus and Aspergillus parasiticus 198 13.2.3 Experimental RNA Silencing During Infection 19913.3 Genetic Analysis of Experimental RNA Silencing 199 13.3.1 Aspergillus nidulans RNA Silencing Model 199 13.3.2
Nancy P. Keller, Thomas M. Hammond
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Science, 2001
In diverse organisms, small RNAs derived from cleavage of double-stranded RNA can trigger epigenetic gene silencing in the cytoplasm and at the genome level. Small RNAs can guide posttranscriptional degradation of complementary messenger RNAs and, in plants, transcriptional gene silencing by methylation of homologous DNA sequences.
Jan M. Kooter +2 more
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In diverse organisms, small RNAs derived from cleavage of double-stranded RNA can trigger epigenetic gene silencing in the cytoplasm and at the genome level. Small RNAs can guide posttranscriptional degradation of complementary messenger RNAs and, in plants, transcriptional gene silencing by methylation of homologous DNA sequences.
Jan M. Kooter +2 more
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RNA silencing and genome regulation
Trends in Cell Biology, 2005Closely related RNA silencing phenomena such as posttranscriptional and transcriptional gene silencing (PTGS and TGS), quelling and RNA interference (RNAi) represent different forms of a conserved ancestral process. The biological relevance of these RNA-directed mechanisms of silencing in gene regulation, genome defence and chromosomal structure is ...
Robin C. Allshire, Ricardo Almeida
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2010
RNA silencing-related mechanisms have been documented in almost all living organisms and RNA silencing is now used as board term to describe the vast array of related processes involving RNA–RNA, RNA–DNA, RNA–protein or protein–protein interactions that ultimately result in the repression of gene expression.
Eamens, Andrew +2 more
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RNA silencing-related mechanisms have been documented in almost all living organisms and RNA silencing is now used as board term to describe the vast array of related processes involving RNA–RNA, RNA–DNA, RNA–protein or protein–protein interactions that ultimately result in the repression of gene expression.
Eamens, Andrew +2 more
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Science, 2000
Eukaryotic cells have developed an elegant system called RNA silencing for getting rid of foreign RNAs whether they be of viral, retrotransposon, or transgene origin. In his Perspective, [Baulcombe][1] examines new findings ([ Wu-Scharf et al .][2]) showing that in a green alga the gene responsible for RNA silencing encodes an RNA helicase (related to ...
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Eukaryotic cells have developed an elegant system called RNA silencing for getting rid of foreign RNAs whether they be of viral, retrotransposon, or transgene origin. In his Perspective, [Baulcombe][1] examines new findings ([ Wu-Scharf et al .][2]) showing that in a green alga the gene responsible for RNA silencing encodes an RNA helicase (related to ...
openaire +2 more sources