Results 301 to 310 of about 1,733,662 (377)

Single-base tiled screen unveils design principles of PspCas13b for potent and off-target-free RNA silencing. [PDF]

Nat Struct Mol Biol
Hu W, Kumar A, Ahmed SF, Qi S, Ma DKG, Chen H, Singh GJ, Casan JML, Haber M, Voskoboinik I, McKay MR, Trapani JA, Ekert PG, Fareh M.   +13 more
europepmc   +1 more source

Lentiviral vector-mediated RNA silencing in the central nervous system.

Human Gene Therapy Methods, 2014
T. Hutson, E. Foster, L. Moon, Rafael J. Yáñez-Muñoz   +3 more
semanticscholar   +1 more source

RPL6 Interacts with HMGCS1 to Stabilize HIF‐1α by Promoting Cholesterol Production in Hepatocellular Carcinoma

Advanced Science, EarlyView.
The study found that RPL6 is frequently upregulated in HCC tissues with extrahepatic metastasis. Elevated RPL6 bound to and increased the stability of HMGCS1 mRNA, thereby enhancing intracellular cholesterol levels. Subsequently, increased cholesterol promotes cancer metastasis in HCC by stabilizing HIF‐1α protein.
Minli Yang, Shengtao Cheng, Huiying Gu, Shan Zhong, Dapeng Zhang, Xin He, Weixian Chen, Haijun Deng, Jihua Ren, Peng Chen, Ming Tan, Hui Zhang, Fan Li, Zhenzhen Zhang, Yuan Hu, Juan Chen   +15 more
wiley   +1 more source

TRBP, a regulator of cellular PKR and HIV‐1 virus expression, interacts with Dicer and functions in RNA silencing

EMBO Reports, 2005
A. Haase, Lukasz Jaskiewicz, Haidi zhang, S. Lainé, R. Sack, A. Gatignol, W. Filipowicz   +6 more
semanticscholar   +1 more source

Ubiquitination‐Dependent LLGL2 Degradation Drives Colorectal Cancer Progression via THBS3 mRNA Stabilization

Advanced Science, EarlyView.
During the progression of CRC, MDM2, as an E3 ubiquitin ligase, promotes the degradation of the LLGL2 protein. Reduced expression of the LLGL2 protein leads to the loss of support for the CNOT1 protein, decreasing the degradation of THBS3 mRNA. The increased THBS3 further activates the PI3K‐Akt pathway, promoting the proliferation and metastasis of CRC.
Jiayan Huang, Tiantian Zhang, Huimin Li, Zidan Li, Shuangshuang Yin, Yiman Liu, Chunze Zhang, Yuling Qiu, Haiyang Yu   +8 more
wiley   +1 more source

Withdrawal: RNA Silencing Identifies PDE4D5 as the Functionally Relevant cAMP Phosphodiesterase Interacting with βArrestin to Control the Protein Kinase A/AKAP79-mediated Switching of the β₂-Adrenergic Receptor to Activation of ERK in HEK293B2 Cells. [PDF]

J Biol Chem
Lynch MJ, Baillie GS, Mohamed A, Li X, Maisonneuve C, Klussmann E, van Heeke G, Houslay MD.   +7 more
europepmc   +1 more source

Silencing in Arabidopsis T-DNA Transformants: The Predominant Role of a Gene-Specific RNA Sensing Mechanism versus Position Effects

, 2004
Daniel Schubert, Berthold Lechtenberg, Alexandra Forsbach, Mario Gils, Sultan Bahadur, Renate Schmidt   +5 more
openalex   +2 more sources

Extracellular LCN2 Binding to 24p3R in Astrocytes Impedes α‐Synuclein Endocytosis in Parkinson's Disease

Advanced Science, EarlyView.
24p3R is an astrocytic receptor for α‐Syn uptake. When LCN2 is secreted from astrocytes, it binds to its receptor 24p3R in astrocytes and this binding impedes the α‐Syn PFF binding to 24p3R. This in turn inhibits 24p3R‐mediated α‐Syn PFF uptake and reduces the clearance of extracellular α‐Syn by astrocytes, which contributes to α‐Syn spread and ...
Ying‐Ying Jiao, Tian Tian, Zhu Zhu, Lei Cao, Yang Liu, Rui‐An Wang, Zhi‐Yong Zhou, Cong Wang, Ke‐Zhong Zhang, Xiao Lu, Wen‐Wei Yun, Ying‐Mei Lu, Gang Hu, Ren‐Hong Du, Ming Lu   +14 more
wiley   +1 more source

Evaluation of the RNA Silencing Suppression Activity of Three Cherry Virus F-Encoded Proteins. [PDF]

Plants (Basel)
Lotos L, Katsiani A, Katis NI, Maliogka VI.   +3 more
europepmc   +1 more source

Oomycete pathogens encode RNA silencing suppressors

Nature Genetics, 2013
Yongli Qiao, Lin Liu, Qin Xiong, Cristina Flores, J. Wong, Jinxia Shi, Xianbing Wang, Xigang Liu, Q. Xiang, Shushu Jiang, Fuchun Zhang, Yuanchao Wang, H. Judelson, Xuemei Chen, Wenbo Ma   +14 more
semanticscholar   +1 more source