Results 141 to 150 of about 447,697 (355)

Viral RNA replication modes: evolutionary and dynamical implications [PDF]

arXiv, 2014
Viruses can amplify their genomes following different replication modes (RMs) ranging from the stamping machine replication (SMR) model to the geometric replication (GR) model. Different RMs are expected to produce different evolutionary and dynamical outcomes in viral quasispecies due to differences in the mutations accumulation rate.
arxiv  

Host- and Strain-Specific Regulation of Influenza Virus Polymerase Activity by Interacting Cellular Proteins

mBio, 2011
Highly pathogenic avian influenza A (HPAI) viruses of the H5N1 subtype have recently emerged from avian zoonotic reservoirs to cause fatal human disease. Adaptation of HPAI virus RNA-dependent RNA polymerase (PB1, PB2, and PA proteins) and nucleoprotein (
Eric Bortz, Liset Westera, Jad Maamary, John Steel, Randy A. Albrecht, Balaji Manicassamy, Geoffrey Chase, Luis Martínez-Sobrido, Martin Schwemmle, Adolfo García-Sastre   +9 more
doaj   +1 more source

Evidence for West Nile Virus and Usutu Virus Infections in Wild and Resident Birds in Germany, 2017 and 2018 [PDF]

, 2019
Wild birds play an important role as reservoir hosts and vectors for zoonotic arboviruses and foster their spread. Usutu virus (USUV) has been circulating endemically in Germany since 2011, while West Nile virus (WNV) was first diagnosed in several bird ...
Eiden, Martin, Fast, Christine, Fischer, Dominik, Groschup, Martin H., Keller, Markus, Korbel, Rüdiger, Lierz, Michael, Lühken, Renke, Michel, Friederike, Müller, Kerstin, Reuschel, Maximilian, Rinder, Monika, Schmidt, Volker, Schmoock, Martina, Schwehn, Rebekka, Sieg, Michael, Urbaniak, Sylvia, Vahlenkamp, Thomas W., Wysocki, Patrick, Ziegler, Ute   +19 more
core   +1 more source

Novel Less Toxic, Lymphoid Tissue‐Targeted Lipid Nanoparticles Containing a Vitamin B5‐Derived Ionizable Lipid for mRNA Vaccine Delivery

Advanced Healthcare Materials, Volume 14, Issue 7, March 14, 2025.
The top‐performing lipid nanoparticle, incorporating a novel ionizable lipid derived from vitamin B5, demonstrates high mRNA transfection efficiency, low toxicity, favorable stability, targeted delivery to lymphoid tissues, and high immunogenicity, showing promise as a carrier for mRNA vaccines for infectious diseases and cancer.
Soyeon Yoo, Muhammad Faisal, Seo‐Hyeon Bae, Kounghwa Youn, Hyo‐Jung Park, Sung Pil Kwon, Il Kwon Hwang, Jisun Lee, Hyeong Jun Kim, Jae‐Hwan Nam, Gyochang Keum, Eun‐Kyoung Bang   +11 more
wiley   +1 more source

HLA-C dysregulation as a possible mechanism of immune evasion in SARS-CoV-2 and other RNA-virus infections. [PDF]

Front Immunol, 2022
Loi E, Moi L, Cabras P, Arduino G, Costanzo G, Del Giacco S, Erlich HA, Firinu D, Caddori A, Zavattari P.   +9 more
europepmc   +1 more source

Encephalomyocarditis Virus Infection of Mouse Plasmacytoma Cells II. Effect on Host RNA Synthesis and RNA Polymerases [PDF]

, 1974
Lawrence B. Schwartz, Charles B. Lawrence, Robert E. Thach, Robert G. Roeder   +3 more
openalex   +1 more source

An unbiased genetic screen reveals the polygenic nature of the influenza virus anti-interferon response. [PDF]

, 2014
Influenza A viruses counteract the cellular innate immune response at several steps, including blocking RIG I-dependent activation of interferon (IFN) transcription, interferon (IFN)-dependent upregulation of IFN-stimulated genes (ISGs), and the activity
Asensio, VJ, Bengoechea, JA, Fernández, Y, Killip, MJ, Oliveros, JC, Ortín, J, Pérez-Cidoncha, M, Randall, RE   +7 more
core   +2 more sources

Delivery of Islatravir via High Drug‐Load, Long‐acting Microarray Patches for the Prevention or Treatment of Human Immunodeficiency Virus

Advanced Healthcare Materials, Volume 14, Issue 7, March 14, 2025.
Islatravir‐loaded dissolving microarray patches (MAPs) provide a minimally invasive, long‐acting solution for HIV‐1 prevention and treatment. In rats, sustained islatravir delivery lasts up to three months, while in minipigs, efficacious plasma levels are detected for six days.
Qonita Kurnia Anjani, Ashley R. Johnson, Akmal H. Sabri, Ryan Lutz, Steven Tignor, Jeanine Ballard, Nathan Rudd, Li Zhao, Lalitkumar K. Vora, Stephanie E. Barrett, Angela Wagner, Ryan F. Donnelly   +11 more
wiley   +1 more source

Immature Brain Cortical Neurons Have Low Transcriptional Competence to Activate Antiviral Defences and Control RNA Virus Infections. [PDF]

J Innate Immun, 2023
Narayanan D, Moily N, McQuilten HA, Kedzierska K, Mackenzie JM, Kedzierski L, Fazakerley JK.   +6 more
europepmc   +1 more source

Recent Applications of Mesoporous Silica Nanoparticles in Gene Therapy

Advanced Healthcare Materials, EarlyView.
The review summarizes the synthesis of mesoporous silica nanoparticles (MSNs) with modifiable surface properties, functionalization strategies, mechanism of therapeutic payload release, and current applications in gene therapy, focusing on their capabilities in the targeted delivery of therapeutic nucleic acids, CRISPR‐Cas systems, and other genetic ...
Tamanna Binte Huq, Punnya Anil Kumar Jeeja, Sudip Kumar Dam, Sabya Sachi Das, Juan L. Vivero‐Escoto   +4 more
wiley   +1 more source