Results 161 to 170 of about 447,697 (355)

Deconvolution of pro- and antiviral genomic responses in Zika virus-infected and bystander macrophages. [PDF]

, 2018
Genome-wide investigations of host-pathogen interactions are often limited by analyses of mixed populations of infected and uninfected cells, which lower sensitivity and accuracy.
Benner, Christopher, Branche, Emilie, Carlin, Aaron F, Glass, Christopher K, Heinz, Sven, Ley, Klaus, Shresta, Sujan, Suarez-Amaran, Lester, Viramontes, Karla M, Vizcarra, Edward A   +9 more
core  

Engineering CAR‐T Therapeutics for Enhanced Solid Tumor Targeting

Advanced Materials, EarlyView.
CART cell therapy has proven effective for blood cancers but struggles with solid tumors due to diverse antigens and complex environments. Recent efforts focus on improving CAR design and validation platforms. Advances in protein engineering, machine learning, and organoid systems aim to enhance CAR‐T therapy against solid tumors.
Danqing Zhu, Won Joon Kim, Hyunjin Lee, Xiaoping Bao, Pilnam Kim   +4 more
wiley   +1 more source

Micro‐ and Nano‐Bots for Infection Control

Advanced Materials, EarlyView.
This review presents a strategic vision for integrating micro‐ and nanobots in the pipeline for infection diagnosis, prevention, and treatment. To develop these robots as a practical solution for infection management, their design principles are clarified based on their propulsion mechanisms and then categorized infection management domains based on ...
Azin Rashidy Ahmady, Shadman Khan, Hong Han, Wei Gao, Zeinab Hosseinidoust, Tohid F. Didar   +5 more
wiley   +1 more source

Adjusting Cell‐Surface Interactions Through a Covalent Immobilization of Biomolecules

Advanced Materials Interfaces, EarlyView.
This review presents an overview of current and emerging immobilization techniques coupled with an in‐depth investigation of the underlying mechanisms governing the activity and stability of covalently immobilized biomolecules. The aim of this study is to serve as a guide for the development of long‐lasting biomedical coatings with versatile biological
Sara Shakibania, Manus J. P. Biggs, Katarzyna Krukiewicz   +2 more
wiley   +1 more source

Human metapneumovirus

Asian Journal of Medical Sciences
Human metapneumovirus (HMPV) is a pre-existing negative sense RNA virus of the family Paramyxoviridae, manifesting lower respiratory tract infections in children and adults above the age of 65 years.
Arghyadeep Dutta , Abhibroto Karmakar , Baburajan Radha , Ruby Dhar , Arun Kumar , Subhradip Karmakar   +5 more
doaj   +1 more source

Quantitative evaluation of hepatitis C virus RNA in patients with concurrent human immunodeficiency virus infections [PDF]

, 1993
Kenneth E. Sherman, Julia O’Brien, A G Gutierrez, Shannon M. Harrison, M S Urdea, Paul Neuwald, Judith C. Wilber   +6 more
openalex   +1 more source

Regulation and functions of the NLRP3 inflammasome in RNA virus infection

Frontiers in Cellular and Infection Microbiology
Virus infection is one of the greatest threats to human life and health. In response to viral infection, the host’s innate immune system triggers an antiviral immune response mostly mediated by inflammatory processes. Among the many pathways involved, the nucleotide-binding oligomerization domain (NOD)-like receptor protein 3 (NLRP3) inflammasome has ...
Zhaoyang Yue, Zhaoyang Yue, Xuelong Zhang, Xuelong Zhang, Yu Gu, Yu Gu, Ying Liu, Ying Liu, Lin-Miaoshen Lan, Lin-Miaoshen Lan, Yilin Liu, Yilin Liu, Yongkui Li, Yongkui Li, Ge Yang, Pin Wan, Pin Wan, Xin Chen, Xin Chen   +18 more
openaire   +3 more sources

Antibiotic‐Mediated Plasmonic‐Mie Resonance for Biosensing Applications on a Novel Silicon Nanopillar Metasurface

Advanced Materials Interfaces, EarlyView.
Unique nanopillar metasurfaces are fabricated for the purpose of sensitive detection to refractive index changes in the presence of gold nanoparticles. The addition of these nanoparticles to the surface of the silicon nanopillars is facilitated via a novel antibiotic‐mediated linker system to promote localized surface plasmon effects resulting from Mie
Jacob Waitkus, JaeWoo Park, Theodore Ndukaife, Sui Yang, Ke Du   +4 more
wiley   +1 more source

Competition-colonization trade-off promotes coexistence of low-virulence viral strains [PDF]

arXiv, 2011
RNA viruses exist as genetically diverse populations displaying different phenotypes, including diverse degrees of virulence. The evolution of virulence in viral populations is, however, poorly understood. Based on the experimental observation of an RNA virus clone in cell culture diversifying into two subpopulations of different virulence, we study ...
arxiv  

RNA N6-methyladenosine methylation in influenza A virus infection

Frontiers in Microbiology
Influenza A virus (IAV) is a negative-sense single-stranded RNA virus that causes acute lung injury and acute respiratory distress syndrome, posing a serious threat to both animal and human health. N6-methyladenosine (m6A), a prevalent and abundant post-transcriptional methylation of RNA in eukaryotes, plays a crucial regulatory role in IAV infection ...
Xueer Liu, Weiqiang Chen, Kangsheng Li, Jiangtao Sheng   +3 more
openaire   +3 more sources