Results 321 to 330 of about 447,697 (355)

Photo‐Biomodulation of the Hippocampus Using Near‐Infrared Laser to Enhance Cognitive Function in Mice

open access: yesAdvanced Science, EarlyView.
Here a transcranial photo‐biomodulation approach is developed using near‐infrared (NIR) laser on hippocampus of mice, revealing significant improvements in learning and memory ability of mice under normal and disease conditions. The improvement results from the high‐density cell‐induced NIR local energy deposition, neuronal activation, and axonogenesis
Wei‐Tong Pan   +6 more
wiley   +1 more source

Human metapneumovirus (hMPV) in 2025: emerging trends and insights from community and hospital-based respiratory panel analyses-a comprehensive review. [PDF]

open access: yesVirol J
Mohammadi K   +10 more
europepmc   +1 more source

Virome and Experimental Analysis Reveal Tryptophan‐Like Dissolved Organic Matter Contributes to the Persistence of Plant Viruses in River Water

open access: yesAdvanced Science, EarlyView.
Tryptophan‐like dissolved organic matter (Try‐like DOM), a key component of organic matter in river ecosystems, demonstrates significant protective effects against plant viruses. The protective mechanism operates via a “swimming firewall” mode, whereby free Try‐like DOM attenuates ultraviolet (UV) radiation and scavenges reactive oxygen species ...
Yujie Wang   +7 more
wiley   +1 more source

Dual‐Locking the SARS‐CoV‐2 Spike Trimer: An Amphipathic Molecular “Bolt” Stabilizes Conserved Druggable Interfaces for Coronavirus Inhibition

open access: yesAdvanced Science, EarlyView.
A new amphipathic molecule, S416 is discovered, that locks the SARS‐CoV‐2 spike protein in its closed state, blocking viral entry. S416 acts as a molecular bolt, binding six sites: three between adjacent RBDs and three connecting NTDs to RBDs. This dual‐locking mechanism stiffens the spike structure and reduces its flexibility.
Shiliang Li   +21 more
wiley   +1 more source

EIDD-2801 resists to infection and co-infection of SARS-CoV-2 and influenza virus. [PDF]

open access: yesVirol J
Qian B   +10 more
europepmc   +1 more source

Recent Advances in mRNA Delivery Systems for Cancer Therapy

open access: yesAdvanced Science, EarlyView.
This review systematically investigates the applications of mRNA therapy in cancer treatment, with particular emphasis on nonviral delivery systems, targeting strategies, stimulus‐responsive systems, and local delivery methods. Concluding with a meticulous evaluation, the review sheds light on the prevailing challenges while illuminating promising ...
Zheng Zhang   +9 more
wiley   +1 more source

Persistent Cervical Infection with the Chikungunya Virus. [PDF]

open access: yesRev Soc Bras Med Trop
Pérez-Pérez JE   +11 more
europepmc   +1 more source

Immunotyping the Tumor Microenvironment Reveals Molecular Heterogeneity for Personalized Immunotherapy in Cancer

open access: yesAdvanced Science, EarlyView.
This study develops TMEclassifier, a machine‐learning tool that classifies cancers into three distinct subtypes—Immune exclusive (IE), immune suppressive (IS), and immune activated (IA)—which exhibit significant heterogeneity and necessitate customized therapeutic strategies.
Dongqiang Zeng   +27 more
wiley   +1 more source

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