Results 61 to 70 of about 253,526 (302)
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
An analysis of the Spanish high capacity road network criticality
, 2018 The analysis of complex networks has been carried out in different fields using an ample variety of method and concepts. Recently, in the general literature of regional economics, the concepts of resilience, connectivity, vulnerability and criticality ...
Moya Gómez, Borja +10 more
core +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
ANALYSIS OF TRAFFIC CAPACITY USING ARCGIS NETWORK ANALYST
Perner’s Contacts, 2014 The article is devoted to the analysis of the road capacity through the town Přerov. The program ArcGIS Network Analyst is used for performing the analysis.
Lucie Váňová, Vít Voženílek
doaj
Highway design on the sections affected by aquaplaning
Mokslas: Lietuvos Ateitis, 2011 Pouring rain, snow melting, water condensing, fog and other natural phenomena cause the collection of water on roadway pavement, leading to the decrease of road-holding capacity of a tyre. When a car or a light truck is moving at a high speed on wet road
Aleksandr Reznik, Andrej Beljatynskij
doaj +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn +4 more
wiley +1 more source
FEBS Open Bio, EarlyView.UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová +2 more
wiley +1 more source
Can Ridesharing Improve the Reserve Capacity of Transportation Network?
IEEE AccessRide-sharing is one of the effective method to reduce car ownership, thus it may have a profound impact on the reserve capacity of road network. However, it’s unclear the relationships among users’ ridesharing behaviors, travel demand ...
Xingyuan Li +3 more
doaj +1 more source