Results 71 to 80 of about 1,687,201 (338)

Dynamic analysis of road vehicle-bridge systems under turbulent wind by means of Finite Element Models [PDF]

open access: yes, 2011
When an automobile passes over a bridge dynamic effects are produced in vehicle and structure. In addition, the bridge itself moves when exposed to the wind inducing dynamic effects on the vehicle that have to be considered.
Antolin Sanchez, Pablo   +3 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

open access: yesMolecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

open access: yesFEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani   +6 more
wiley   +1 more source

Stress Analysis of Existing Underground Gas Pipeline due to New Road Crossing with ODOL Transportation

open access: yesJGEET: Journal of Geoscience, Engineering, Environment and Technology, 2023
Pipelines are the main choice for transport oil and gas due to its resilience, reliability, safety, and lower cost. Most road crossing pipelines are located underground where protections from the loads can be used such as additional pavement. Underground
Taqiya Tsamara, IGN Wiratmaja Puja
doaj   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

open access: yesAging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu   +8 more
wiley   +1 more source

Vibroisolation of railway crossings with the application of shape-memory elements [PDF]

open access: yesTransport Problems, 2009
This research presents existing problem of railway elements and motor –vehicle road elements at their intersections. The objects of simulation research were vehicles passing over a level crossing of automobile road and rail-transportation road. Objective
Jan TARGOSZ
doaj  

Method for a structured identification of suitable safety and securing systems for Level Crossings [PDF]

open access: yes, 2009
Safety and securing systems for level crossing have a long life time. Once a system reaches a life time when it is no longer conform to applicable regulations, it has to be modernized or replaced.
Asbrock, Hartwig   +2 more
core  

Exploring Patients’ Profiles Associated With the Resolution of Acute Calcium Pyrophosphate Arthritis Treated With Colchicine and Prednisone: Post Hoc Analysis of a Randomized Controlled Trial

open access: yesArthritis Care &Research, EarlyView.
Objective The objective was to identify factors determining acute arthritis resolution and safety with colchicine and prednisone in acute calcium pyrophosphate (CPP) crystal arthritis. Methods We conducted a post hoc analysis of the COLCHICORT trial, which compared colchicine and prednisone for the treatment of acute CPP crystal arthritis, using a ...
Tristan Pascart   +14 more
wiley   +1 more source

Automatic Estimation of the Exposure to Lateral Collision in Signalized Intersections using Video Sensors [PDF]

open access: yes, 2010
Intersections constitute one of the most dangerous elements in road systems. Traffic signals remain the most common way to control traffic at high-volume intersections and offer many opportunities to apply intelligent transportation systems to make ...
Midenet, Sophie, Saunier, Nicolas
core  

A Qualitative Analysis of Patient Perspectives and Preferences in Lupus Management to Guide Lupus Guidelines Development

open access: yesArthritis Care &Research, EarlyView.
Objective A patient‐centered approach for chronic disease management, including systemic lupus erythematosus (SLE), aligns treatment with patients’ values and preferences, leading to improved outcomes. This paper summarizes how patient experiences, perspectives, and priorities informed the American College of Rheumatology (ACR) 2024 Lupus Nephritis (LN)
Shivani Garg   +20 more
wiley   +1 more source

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