Results 41 to 50 of about 294,721 (265)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Combining 2D and 3D features to improve road detection based on stereo cameras
IET Computer Vision, 2018 Road detection is a fundamental component of autonomous driving systems since it provides validspace and candidate regions of objects for driving decision. The core of roaddetection methods is extracting effective and discriminative features.
Guorong Cai +4 more
doaj +1 more source
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
Remote SensingSpaceborne infrared small-target detection plays a critical role in space-sky early warning, disaster rescue, and reconnaissance tracking, benefiting from all-time, all-weather, and wide-area monitoring capabilities.
Xiaoying Wu +4 more
doaj +1 more source
FEBS Letters, EarlyView.The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson +6 more
wiley +1 more source
Infrared Temporal Differential Perception for Space-Based Aerial Targets
Remote SensingSpace-based infrared (IR) detection, with wide coverage, all-time operation, and stealth, is crucial for aerial target surveillance. Under low signal-to-noise ratio (SNR) conditions, however, its small target size, limited features, and strong clutters ...
Lan Guo +4 more
doaj +1 more source
Buildings, 2023 Due to the harsh application environment, sodium sulfate corrosion poses a considerable threat to the performance of reinforced concrete. Considering high fluidization and early strength cement grouts (HECG) are widely adopted in the repair engineering ...
Yinshan Xu, Jianqiang Zhou, Sujing Jin
doaj +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source