Results 121 to 130 of about 15,043 (304)

Heat Shock Protein 90: From Molecular Chaperone Function to Therapeutic Targeting in Malignancies

open access: yesAdvanced Science, EarlyView.
In this review, an integrated conceptual framework linking HSP90's molecular chaperone functions to its pathological roles in cancer is proposed. HSP90 serves as a central node that integrates oncogenic signaling, buffers proteotoxic stress, maintains cancer stem cell plasticity, and shapes tumor‐immune interactions, all of which converge to drive ...
Beibei Zhang   +4 more
wiley   +1 more source

Understanding freight-built environment interrelationships. [PDF]

open access: yes
DTRT06-G-0020The main aim of this study is to advance the understanding of interactions among land use,transportation infrastructure, and movement of freight.
National Center for Freight and Infrastructure Research and Education (U.S.)
core  

Perth freight link: good idea, wrong port [PDF]

open access: yes, 2015
The Perth Freight Link (PFL) has been announced as a major transport opportunity to solve the heavy goods truck problems in Perth. By taking trucks via a toll road around an extended Roe Highway, through Stock Road and Leach Highway to the Fremantle ...
Cole Hendrigan, Peter Newman
core  

CO2 efficiency in road freight transportation: status quo, measures and potential

open access: yes, 2004
Road freight transport continues to grow in Germany and generates 6% of the country’s CO2 emissions. In logistics, many decisions influence the energy efficiency of trucks, but causalities are not well understood. Little work has been done on quantifying
Leonardi, J., Baumgartner, M.
core   +1 more source

Engineered Exosomal miR‐146a‐5p Reprograms BMSC Fate and Restores Mitochondrial Homeostasis in Glucocorticoid‐Induced Osteonecrosis of Femoral Head

open access: yesAdvanced Science, EarlyView.
Exosomal miR‐146a‐5p is identified as a pivotal regulator in steroid‐induced osteonecrosis. Its reduction activates NF‐κB signaling, compromises mitophagy, and disrupts mitochondrial bioenergetics, resulting in autophagic disequilibrium. Engineered exosomes delivering miR‐146a‐5p reinstate mitochondrial function, augment oxidative phosphorylation and ...
Zehui Lv   +13 more
wiley   +1 more source

Urban Freight and Road Safety: Trends and Innovative Strategies [PDF]

open access: yes
Collaborative Sciences Center for Road Safety R30The increasing freight demand in recent decades has posed road safety threats on urban local communities.
McDonald, Noreen   +9 more
core  

Value proposition in international freight : the contribution of the freight forwarder to the global logistics triad [PDF]

open access: yes, 2001
The freight forwarder has been threatened with 'disintermediation' for years. This research looks at the relationships in the global logistics triad comprising the forwarder, the shipper, and the airline or ocean carrier.
Ford, Richard
core  

Sub‐Terahertz Memristor Switches Using MoS2 by Liquid–Liquid Interface Assembly

open access: yesAdvanced Science, EarlyView.
This work introduces application‐ready sub‐terahertz memristor switches fabricated from electrochemically exfoliated MoS2 nanosheets assembled at a liquid–liquid interface. The devices exhibit robust unipolar resistive switching, low insertion loss, and high isolation across 10–110 GHz.
Tomás Mingates   +15 more
wiley   +1 more source

International road and rail freight transport: the impact of globalisation on activity levels

open access: yes, 2010
This chapter establishes the recent trends in international trade volumes. It then aims to identify the main ways in which this trade growth has affected road and rail freight transport activity at the international level, and finally considers the ...
Leonardi, J.   +4 more
core  

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