Results 41 to 50 of about 151,652 (249)

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Actions for the Optimization of Russian – Indian Trade Cooperation

Vestnik MGIMO-Universiteta, 2013
The article describes current stage of the Russian-Indian trade-economic cooperation. The Author analyses the issues which business have to face approaching the markets of Russia and India. Special emphasis is laid on the measures for the optimization of
A. D. Bondarenko
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Development highlights of micro-nano technologies in the MENA region and pathways for initiatives to support and network

Green Processing and Synthesis, 2013
Current developments in the field of micro-nano technologies in the Middle East and North Africa (MENA) region are highlighted. Firstly, the scientific outcome of micro-nano technologies from the MENA region is analyzed.
Al-Rawashdeh Ma’moun, Alfeeli Bassam, Rawashdeh Abdel Monem, Hessel Volker   +3 more
doaj   +1 more source

Environmental pollutants and the obesity: Proven causalities and open questions [PDF]

Arhiv za farmaciju
The link between environmental pollution and obesity is of high importance, because understanding the relationship between the two can provide valuable insights into the complex factors contributing to the obesity epidemic.
Ćurčić Marijana, Esteban Javier, Cakmak Gonca, Durgo Ksenija, Baralić Katarina, Živanović Jovana, Marić Đurđica, Buha-Đorđević Aleksandra, Antonijević-Miljaković Evica, Bulat Zorica, Antonijević Biljana, Đukić-Ćosić Danijela   +11 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Vehicle position estimation based on road area detection and image registration

Nihon Kikai Gakkai ronbunshu, 2017
This paper describes the development of a new localization method using a simple 2D map. The general method for localization using a 2D map is to match between the boundary line on the 2D map and the detected boundaries in the real world, i.e.
Keisuke KAZAMA, Toshiki KAWAKATSU, Yasuhiro AKAGI, Hiroshi MOURI   +3 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Mapping Remote Roads Using Artificial Intelligence and Satellite Imagery

Remote Sensing
Road building has long been under-mapped globally, arguably more than any other human activity threatening environmental integrity. Millions of kilometers of unmapped roads have challenged environmental governance and conservation in remote frontiers ...
Sean Sloan, Raiyan R. Talkhani, Tao Huang, Jayden Engert, William F. Laurance   +4 more
doaj   +1 more source