Results 71 to 80 of about 1,135,376 (250)
FEBS Open Bio, EarlyView.We analyzed alterations of PAR metabolism‐related proteins in PARG inhibitor‐resistant HCT116RPDD cells. Although PARG levels remained unchanged, HCT116RPDD cells exhibited reduced PARP1 and ARH3 expression and elevated PAR levels. Interestingly, HCT116RPDD cells exhibited slightly elevated intracellular NAD+/NADH and ATP levels. Our findings suggest a
Kaede Tsuda, Yoko Ogino, Akira Sato
wiley +1 more source
Working as one: a road map to disaster resilience for Australia [PDF]
, 2014 This report offers a roadmap for enhancing Australia’s disaster resilience, building on the 2011 National Strategy for Disaster Resilience. It includes a snapshot of relevant issues and current resilience efforts in Australia, outlining key challenges ...
Anthony Bergin +2 more
core +1 more source
A Force-Directed Approach for Offline GPS Trajectory Map Matching
, 2019 We present a novel algorithm to match GPS trajectories onto maps offline (in batch mode) using techniques borrowed from the field of force-directed graph drawing.
Cudré-Mauroux, Philippe +2 more
core +1 more source
FEBS Open Bio, EarlyView.Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn +4 more
wiley +1 more source
FEBS Open Bio, EarlyView.Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu +10 more
wiley +1 more source
Collective Impact Case Study: The Road Map Project [PDF]
, 2013 The Road Map Project seeks to double the number of students on track to graduate with a postsecondary degree or career credential in the South Seattle and South King County, Wash., region by 2020, as well as to close achievement gaps.
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FEBS Open Bio, EarlyView.This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel +4 more
wiley +1 more source
ICT Road map for supporting energy systems in smart cities [PDF]
, 2014 This paper introduces a road map for ICTs (Information and communication technologies) supporting planning, operation and management of energy systems in smart cities.
Fiès, Bruno +2 more
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Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
A road map for interoperable language resource metadata [PDF]
, 2010 LRs remain expensive to create and thus rare relative to demand across languages and technology types. The accidental re-creation of an LR that already exists is a nearly unforgiveable waste of scarce resources that is unfortunately not so easy to avoid.
Calzolari, Nicoletta +7 more
core +1 more source