Results 131 to 140 of about 919,114 (299)

Genetically‐Programmed Hypervesiculation of Lactiplantibacillus Plantarum Increases Production of Bacterial Extracellular Vesicles with Therapeutic Efficacy in a Preclinical Inflammatory Bowel Disease Model

open access: yesAdvanced Science, EarlyView.
The development of a novel engineered strain of Lactiplantibacillus plantarum (Lp) is reported that can produce bacterial extracellular vesicles (BEVs) at >60‐fold higher yields than the unmodified parental strain. These Lp BEVs retain therapeutic bioactivity as validated in a mouse model of dextran sodium sulfate‐induced colitis.
Nicholas H Pirolli   +16 more
wiley   +1 more source

Conceptualising quality early childhood education: Learning from young children in Brazil and South Africa through creative and play‐based methods

open access: yesBritish Educational Research Journal, EarlyView., 2023
Abstract Early childhood has increasingly been acknowledged as a vital time for all children. Inclusive and quality education is part of the United Nations Sustainable Development Goals, with the further specification that all children have access to quality pre‐primary education.
Laura H. V. Wright   +8 more
wiley   +1 more source

Epidemiological, clinical, and therapeutic aspects of limb trauma related to road traffic accidents at Bonassama district hospital [PDF]

open access: diamond
Nyekel Justine Raphaela   +6 more
openalex   +1 more source

Genome‐scale Metabolic Modeling Guided Escherichia coli Engineering for De Novo Biosynthesis of Chrysanthemic Acid

open access: yesAdvanced Science, EarlyView.
Genome‐scale metabolic modeling is preceded to the engineered E. coli cell factory for the de novo biosynthesis of biopesticide chrysanthemic acid. The debranching strategy redirects metabolic flux, enhancing precursor and target compound production.
Jiangpeng Yu   +6 more
wiley   +1 more source

Dynamic Time-Dependent Route Planning in Road Networks with User Preferences

open access: yes, 2015
There has been tremendous progress in algorithmic methods for computing driving directions on road networks. Most of that work focuses on time-independent route planning, where it is assumed that the cost on each arc is constant per query.
Baum, Moritz   +3 more
core  

ARL5B Drives Esophageal Squamous Cell Carcinoma Progression via ROCK1–SREBP1‐Mediated Lipid Metabolic Reprogramming

open access: yesAdvanced Science, EarlyView.
Esophageal squamous cell carcinoma urgently requires new therapeutic strategies. Adenosine diphosphate‐ribosylation factor‐like protein 5B (ARL5B) is identified as a novel oncogene that remodels fatty acid metabolism through the ras homologous‐associated coiled‐coil containing protein kinase 1 (ROCK1)–sterol regulatory element‐binding protein 1 (SREBP1)
Xinyue Ma   +12 more
wiley   +1 more source

THE INTRODUCTION OF THE METHODOLOGY TO IMPROVE ROAD SAFETY

open access: yesНаука и техника, 2013
Recommendations for improving the road safety and quality of road traffic controlled junctions(crossings) on individual parameters of traffic light control, improvement of traffic light control by optimizing the length of the transition interval in the ...
D. V. Kapsky, A. I. Ryabchinsky
doaj  

Traffic coordination at road intersections: Autonomous decision-making algorithms using model-based heuristics

open access: green, 2017
Gabriel Rodrigues de Campos   +4 more
openalex   +2 more sources

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