Results 51 to 60 of about 1,740,224 (358)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

A Model for Predicting Short-Term Operating Speeds of Compact Passenger Vehicles on Interchange Ramps Within Urban Expressway Networks

Journal of Advanced Transportation
The prediction of operating speed plays a crucial role in road design and safety assessment, especially on complex urban expressway interchange ramps. This task is challenging due to various influences like road conditions, traffic dynamics, and driver ...
Tingyu Liu, Lanfang Zhang, Genze Li, Yating Wu, Zhenyu Zhao   +4 more
doaj   +1 more source

A study of the impact of traffic investment on traffic fatalities in China, 2004 – 2020

Chinese Journal of Traumatology
Purpose: Road traffic injuries (RTIs) have been one of the most serious public health problems in China. The purpose of this study was to investigate the extent to which traffic investment affects traffic fatalities in China as well as regional ...
Li-Lu Sun, Shan Liu, Tian Lan, Xi-Ping Zou   +3 more
doaj   +1 more source

Associations of Combined Exposures to Surrounding Green, Air Pollution, and Road Traffic Noise with Cardiometabolic Diseases

Environmental Health Perspectives, 2019
Background: Surrounding green, air pollution, and noise have been associated with cardiometabolic diseases, but most studies have assessed only one of these correlated exposures.
J. Klompmaker, N. Janssen, L. Bloemsma, U. Gehring, A. Wijga, Carolien L. van den Brink, E. Lebret, B. Brunekreef, G. Hoek   +8 more
semanticscholar   +1 more source

Autophagosome marker, LC3, is released extracellularly via several distinct pathways

FEBS Open Bio, EarlyView.
This study establishes a novel HiBiT‐tagging system for ultrasensitive detection of LC3, revealing multiple pathways for its extracellular secretion. It demonstrates that LC3 is released via both autophagy‐dependent and ‐independent mechanisms, including a novel route for nonlipidated LC3‐I.
Koki Saito, Masashi Arakawa, Koki Maeda, Eiji Morita   +3 more
wiley   +1 more source

Analysis of the Impact of Traffic Violation Monitoring on the Vehicle Speeds of Urban Main Road: Taking China as an Example

Journal of Advanced Transportation, 2020
In recent years, there are more and more applications of traffic violation monitoring in some countries. The present work aims to analyze the vehicle speeds nearby road traffic violation monitoring area on urban main roads and find out the impact of road
Fuquan Pan, Yongzheng Yang, Lixia Zhang, Changxi Ma, Jinshun Yang, Xilong Zhang   +5 more
doaj   +1 more source

Pharmacokinetics, Pharmacodynamics, and Safety of Subcutaneous Belimumab in Pediatric Patients with Systemic Lupus Erythematosus: A Multicenter, Open‐Label Trial

Arthritis Care &Research, Accepted Article.
Objective This study aimed to characterize the pharmacokinetics, pharmacodynamics, safety, and exploratory efficacy of subcutaneous belimumab in pediatric patients with active systemic lupus erythematosus (SLE) receiving standard therapy. Methods This single‐arm, multicenter, open‐label trial (GSK study 200908; NCT04179032) used three‐weight‐band ...
Hermine I. Brunner, Jordi Antón, Inmaculada Calvo‐Penadés, Richard Dimelow, Gerd Horneff, Sylvia Kamphuis, Rebecca Marino, Andre van Maurik, Kirsten Minden, Masaaki Mori, Josephine Ocran‐Appiah, Christel Wilkinson, Yuichi Yamasaki, Deepak Assudani, for the Pediatric Rheumatology Collaborative Study Group (PRCSG) and Paediatric Rheumatology International Trials Organisation (PRINTO) network investigators   +14 more
wiley   +1 more source

A Collaborative Monitoring Method for Traffic Situations under Urban Road Emergencies

Applied Sciences, 2023
The complex and diverse urban road traffic environments make it difficult to accurately assess road traffic situations. This paper proposes a collaborative monitoring method for urban road traffic situational assessment during emergency events.
Min Xiang, Yulin An
doaj   +1 more source

Road traffic injuries measures in the Eastern Mediterranean Region: findings from the Global Status Report on Road Safety – 2015

Journal of Injury and Violence Research, 2019
: Background: The Eastern Mediterranean Region has the second highest road traffic fatality rate in the world. This article presents the epidemiology of road traffic injuries and the preventive measures in Eastern Mediterranean Region taken by the ...
Soori Hamid, K. Davoud
semanticscholar   +1 more source

Next‐Generation Bio‐Reducible Lipids Enable Enhanced Vaccine Efficacy in Malaria and Primate Models

Advanced Functional Materials, EarlyView.
Structure–activity relationship (SAR) optimization of bio‐reducible ionizable lipids enables the development of highly effective lipid nanoparticle (LNP) mRNA vaccines. Lead LNPs show superior tolerability and antibody responses in rodents and primates, outperforming approved COVID‐19 vaccine lipids.
Ruben De Coen, Sabah Kasmi, Shrinivas Dumbre, Lies Baekens, Elise Seynaeve, Louise Van den Hauwe, Niccolò Cantini, Aello Garantoudi, Filipe Branco Madeira, Alain Marrot, Emma Tuypens, Sofie Seghers, Anna Kuchmiy, Elisabeth Brabants, Bart Vanderborght, Ine Maes, Sarah Vandenberghe, Jessica Filtjens, Alícia Gordún Peiró, Daliya Kancheva, Ayla Debraekeleer, Florence Lambolez, Emily De Lombaerde, Yong Chen, Rafael Miyazawa Martins, Pauline Formaglio, Damya Laoui, Sofie Deschoemaeker, Bruno G. De Geest, Rogerio Amino, Stefaan De Koker   +30 more
wiley   +1 more source