Results 161 to 170 of about 2,416,136 (291)

Precision therapies for genetic epilepsies in 2025: Promises and pitfalls

open access: yesEpilepsia Open, EarlyView.
Abstract By targeting the underlying etiology, precision therapies offer an exciting paradigm shift to improve the stagnant outcomes of drug‐resistant epilepsies, including developmental and epileptic encephalopathies. Unlike conventional antiseizure medications (ASMs) which only treat the symptoms (seizures) but have no effect on the underlying ...
Shuyu Wang   +3 more
wiley   +1 more source

Evaluation of City Planning Road Development Measures by Microscopic Traffic Simulation [PDF]

open access: yes
This study was made on the development plan of Kawahara Avenue, a road project authorized in city planning of Miyazaki City in Japan. The Kawahara Avenue development is planned along the Oyodo River. The land use of the area along the route comprises the
Tetsunobu Yoshitake   +4 more
core  

Status epilepticus: Updates on mechanisms and treatments

open access: yesEpilepsia Open, EarlyView.
Abstract Status epilepticus (SE) consists of prolonged, self‐sustaining seizures and is a common neurological emergency that causes respiratory compromise and neuronal injury. Without prompt treatment, the seizures can become resistant to benzodiazepines, leading to the progressive evolution of established, refractory, and super‐refractory SE.
Suchitra Joshi, Jaideep Kapur
wiley   +1 more source

Engineering mRNA‐LNP Medicines for the Ageing Brain: Opportunities and Challenges for Neurodegenerative Diseases

open access: yesExploration, EarlyView.
This review highlights recent advances in engineering messenger RNA (mRNA)‐lipid nanoparticles (LNPs) to cross the ageing blood–brain barrier and target neurodegenerative diseases. It outlines design principles, delivery routes, and translational challenges, charting a roadmap towards clinical application of mRNA‐LNP therapeutics for neurodegenerative ...
Abdel Ali Belaidi   +5 more
wiley   +1 more source

Performing history, negotiating patriarchy: Actressing as gendered labor and the fragmentation of womanhood in Chinese historical costume drama

open access: yesFeminist Anthropology, EarlyView.
Abstract Gender inequality remains widespread in the film and television production industry, yet it is seldom examined in relation to backstage working environments. This article integrates on‐screen and off‐screen perspectives to investigate the working lives of Chinese actresses.
Yajie Li, Yuhao Ding
wiley   +1 more source

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