Results 51 to 60 of about 36,542 (258)

Secreted Nonstructural Protein 3 is a Pathogenic Determinant of Orbivirus

Advanced Science, EarlyView.
This study uncovers a conserved PIP2‐dependent secretory pathway of orbivirus NS3 that induces vascular leakage. Pharmacological disruption of PIP2‐NS3 interaction significantly reduces viral pathogenicity and provides protective efficacy in murine models, establishing PIP2‐mediated NS3 secretion as both a key virulence determinant and a promising ...
Junyong Guan, Dong Zhou, Ran Shao, Xing Liu, Jin Peng, Yingran Huang, Shuhui Qi, Cankun Xi, Menghang Wang, Bin Sun, Yinglin Qi, Xin Yin   +11 more
wiley   +1 more source

PERSIAN traffic safety and health cohort: a population-based precrash cohort study

BMJ Open
Purpose Despite to high burden of road traffic injuries (RTIs), the RTI epidemiology has received less attention with rare investments on robust population cohorts. The PERSIAN Traffic Safety and Health Cohort (PTSHC) was designed to assess the potential
Homayoun Sadeghi-Bazargani, Mostafa Farahbakhsh, Mina Golestani, Morteza Ghojazadeh, Reza Mohammadi, Faramarz Pourasghar, Sajjad Ahmadi, Alireza Razzaghi, Mehdi Rezaei, Leila Vahedi, Alireza Shafiee-kandjani, Mohammad Meshkini, Fatemeh Jahanjoo, Mir Bahador Yazdani, Elham Davtalab Esmaeili, Ali Jafari-Khounigh   +15 more
doaj   +1 more source

The efficacy of inferior vena cava diameters and the jugular vein in assessing fluid resuscitation [PDF]

Journal of Emergency Practice and Trauma, 2019
Objective: Fluid resuscitation is necessary in almost all critical patients. The central venous pressure (CVP) is a well-established method of assessing resuscitation.
Nahid Zamanimehr
doaj   +1 more source

Natural Resistance to Ovarian Hyperstimulation Syndrome in Estrildid Finches Reveals Macrophage GPR183 as a Potential Therapeutic Target

Advanced Science, EarlyView.
Ovarian macrophage depletion reverses OHSS resistance in estrildid finches and exacerbates OHSS symptoms in rats. Activating macrophage GPR183 alleviates OHSS by reducing pro‐inflammatory factors, increasing immunomodulatory molecules, remodeling CD44/SDC4‐mediated communication, and restoring immune homeostasis.
Xiaofei Yan, Yongjie Huang, Jiabao Yang, Su Ma, Songsong Liu, Xuan Huang, Juergen Brosius, Huaping Zheng, Bing Yao, Li Chen, Shanshan Lai, Cheng Deng   +11 more
wiley   +1 more source

A longitudinal study of suicide and suicide attempt in northwest of Iran: incidence, predictors, and socioeconomic status and the role of sociocultural status

BMC Public Health, 2021
Background A detailed community-level understanding of socioeconomic status (SES) and sociocultural status (SCS) of suicides and suicide attempters (SAs) in a prospective design could have significant implications for policymakers at the local prevention
Ali Fakhari, Mostafa Farahbakhsh, Elham Davtalab Esmaeili, Hosein Azizi   +3 more
doaj   +1 more source

Pathogen‐Centric Activation of an Azoreductase‐Responsive Antibody‐Antibiotic Conjugate for the Targeted Eradication of MRSA

Advanced Science, EarlyView.
A pathogen‐centric antibody‐antibiotic conjugate (AZO‐AAC) releases antibiotics via bacterial azoreductase, independent of host‐lysosomal function. This mechanism achieves nanomolar eradication of both planktonic and intracellular methicillin‐resistant Staphylococcus aureus (MRSA).
Qi Cheng, Lianqi Liu, Chenghua Liu, Fei Xie, Jingwen Dong, Xiaoyu Qin, Shunxiang Huang, Xian Li, Xingyuan Kou, Hongbin Deng, Jiannan Feng, Wu Zhong, Dian Xiao, Xinbo Zhou   +13 more
wiley   +1 more source

Effective suicide prevention strategies in primary healthcare settings: a systematic review

Middle East Current Psychiatry, 2022
Background There is a fundamental need for health systems, health managers, and policymakers to identify effective components of suicide prevention strategies (SPS) and programs in primary healthcare (PHC) settings.
Hosein Azizi, Elham Davtalab Esmaeili, Farzad Khodamoradi, Ehsan Sarbazi   +3 more
doaj   +1 more source

A Microgel Platform Enables Site‐Specific Intestinal Delivery of Lactoferrin, Improving its Bioavailability for Targeted Alleviating Liver Injury and Colitis

Advanced Science, EarlyView.
This work first time reports an eco‐friendly desert plant food‐based polysaccharide ASKP microgels which have intestinal site‐specific release properties which can achieve small‐intestine or colon targeting capability via different cross‐linking chemistry.
Huiling Yan, Yixuan Li, Shanan Chen, Pengcheng Du, Kaiwen Wu, Hui Zhang, Kasper Hettinga, Lina Zhang, Gergely Toldi, Fazheng Ren, Yuan Li   +10 more
wiley   +1 more source

A closer look at depression and sleep quality relation: A cross‐sectional study of taxi drivers in Tabriz metropolis

Health Science Reports
Background and Aim Taxi drivers play a significant role in urban mobility and safety as professional drivers. They typically have poor incomes, long work hours, lack of sleep, and high levels of stress, which increase the risk of physical and mental ...
Leili Abedi, Mohammad Bagher Naghizad, Zeinab Habibpour, Kavous Shahsavarinia, Mir Bahador Yazdani, Mohammad Saadati   +5 more
doaj   +1 more source

Developing a national road traffic safety education program in Iran

BMC Public Health, 2020
Background Education is a pivot included Decade of Action for Road Safety initiative, which has reduced deaths caused by accidents in developed countries. Given the circumstances of each country, a proper education program is necessary.
Fatemeh Bakhtari Aghdam, Homayoun Sadeghi-Bazargani, Saber Azami-Aghdash, Alireza Esmaeili, Haneieh Panahi, Maryam Khazaee-Pool, Mina Golestani   +6 more
doaj   +1 more source