Results 151 to 160 of about 10,441 (309)

Exosome‐mediated gut–brain axis signaling in neurodegenerative diseases: Mechanisms, experimental evidence, and therapeutic perspectives—A narrative review

Animal Models and Experimental Medicine, EarlyView.
The gut–brain axis is a bidirectional communication network between the intestines and brain, mediated by gut microbiota and exosomes, that regulates neuroinflammation, protein aggregation, and neuronal health processes central to neurodegenerative diseases.
Waheeb Sami Aggad, Rakesh Ghosh, Hailah M. Almohaimeed, Zuhair M. Mohammedsaleh, Fayez M. Saleh, Amany I. Almars, S. Renuka Jyothi, Rajashree Panigrahi, Ajoy Kumer, Bikram Dhara   +9 more
wiley   +1 more source

Multimodal Freight Transport Planning: A Toolbox Supporting Stakeholders’ Collaboration

, 2019
This paper aims to analyse the planning of chemical transports’ shift from road to the more complex multimodal freight transport, and presents a toolbox developed to support the stakeholders in the process.
Cichosz, Marzenna; SGH Warsaw School of Economics, Department of Transport
core  

Therapeutic Applications of Stimuli‐Based Release and Engineering of Extracellular Vesicles

Advanced NanoBiomed Research, EarlyView.
This review summarizes the effects of endogenous and exogenous stimuli, their effects on the natural release of extracellular vesicles, as well as their uptake and release. It also gives an overview of stimuli‐responsive EVs and their therapeutic applications. Extracellular vesicles (EVs), nano‐ to microsized lipid bilayer membrane‐bound particles, are
Gloria Kemunto, Kristen Dellinger
wiley   +1 more source

Comparison of Receptor‐Mediated Endocytosis and Its Application to Enhance DNA Transfection by TFAMoplex

Advanced NanoBiomed Research, EarlyView.
We developed an assay to distinguish cellular binding from internalization. Compatible with microscopy and high‐throughput screening, the method identifies ligand‐mediated uptake. Applying top candidates to a protein‐based DNA carrier enhanced transfection efficiency, providing a rational strategy to improve non‐viral gene delivery systems.
David Scherer, Steffen Honrath, Jonas Kurmann, Alexander Klipp, Finn Brigger, Jean‐Christophe Leroux   +5 more
wiley   +1 more source

PEG Alternatives in Liposomal Nanocarriers: Physicochemical Characteristics and Sustainable Process Strategies

Asia-Pacific Journal of Chemical Engineering, EarlyView.
ABSTRACT The global trend toward sustainable and intensified bioprocesses is driving innovation in the design and scalable synthesis of liposomal nanocarriers, a cornerstone of modern drug delivery. For decades, these nanosystems have relied exclusively on polyethylene glycol (PEG) for their sustained circulation in vivo, but they are currently ...
Chandra Has
wiley   +1 more source

The potential role of truck-hailing and operational efficiency improvement in China's road freight decarbonization. [PDF]

Nat Commun
Xu X, Ou S, Peng T, Lin Z, Ou X, Xu Z, Gan M, Li D, Liu X.   +8 more
europepmc   +1 more source

Optimizing Strategies for Non‐Invasive Prospection of Settlements in the Intertidal Zone: A Case Study From the Centre of the Drowned Medieval Village of Tolsende (Scheldt Estuary, the Netherlands)

Archaeological Prospection, EarlyView.
ABSTRACT Medieval and early modern drowned villages in the intertidal zone of the Scheldt estuary (the Netherlands) constitute intriguing yet largely understudied components of north‐western Europe's underwater cultural heritage. Despite their high archaeological potential as time capsules of past settlement landscapes, research has remained limited ...
Jan Trachet, Sarah Bäumler, Stefan Krojer, Jeroen Verhegge, Wim De Clercq, Philippe De Smedt, Wouter H. Maes, Bente S. Majchczack, Immo Trinks, Dennis Wilken   +9 more
wiley   +1 more source

Dataset to support the modelling of Vietnam's transport sector: population, economy, transport activity, energy intensity, load capacity, and carbon emission. [PDF]

Data Brief
Tan N, Kiley F, Dalkmann H, Zilliacus J, Harrison J, Howells M, Foster V.   +6 more
europepmc   +1 more source

The impact of the Maputo Development Corridor on freight flows: an initial investigation

, 2000
This paper provides an analysis of the effect of the Maputo Development Corridor (MDC) on freight flows between Mozambique and South Africa. By analysing the transport infrastructure of the MDC, this paper seeks to provide insight into the relationship ...
Driver, Amanda, de Barros, Joao Gabriel
core  

Mapping opioid exposure through prescription data and postmortem analysis of opioid drugs in multiple tissues

British Journal of Clinical Pharmacology, EarlyView.
Background and Purpose Although opioids are central to end of life (EoL) care, tissue‐level opioid exposure remains poorly understood. The objective of this study was to characterize the relationship between prescription‐derived morphine equivalent daily dose (MEDD) and measured morphine concentrations across multiple organs.
Niamh Higgins, Alan Wells, Nimish Patel, Nicole Muttera, Mattia Trunfio, Alessandra Manca, Amedeo De Nicolò, Micol Ferrara, Stefano Bonora, Jessica Cusato, Alice Palermiti, Antonio D'Avolio, Marissa Borochoff, Patricia K. Riggs, Elizabeth Hastie, Rabia S. Atayee, Stephanie Solso, Cheryl Dullano, Vanessa Gomez‐Moreno, Tara Tenenbaum, Robert Deiss, Davey M. Smith, Antoine Chaillon, Sara Gianella   +23 more
wiley   +1 more source