A Small‐Molecule DEPTAC Rescues Cognitive Deficits by Targeted Dephosphorylation of Pathological Tau
TP2 is a fully synthetic small‐molecule dephosphorylation‐targeting chimera that recruits endogenous PP2A‐Bα to Tau, enabling targeted removal of pathological phosphate modifications. In two tauopathy mouse models, systemic TP2 reduces Tau pathology, preserves neuronal and synaptic integrity, improves neuroimmune homeostasis, and rescues cognition ...
Fei Sun +12 more
wiley +1 more source
Optimizing the potential use of waste palm oil clinker powder in cementitious grouts for semiflexible pavements using response surface methodology. [PDF]
Khan N +7 more
europepmc +1 more source
A metasurface‐enabled helical wavefront fingerprint (MHWF) paradigm is proposed for quantitative and specific retrieval of a liquid medium's refractive index and extinction coefficient. The liquid's complex dielectric response governs the wavefront evolution of the metasurface‐generated focused vortex beam, forming a distinctive three‐dimensional ...
Yuting Zhou +10 more
wiley +1 more source
Research Progress of Electrically Conductive Asphalt Concrete Deicing and Snowmelt Technology: Material Development and Application Progress. [PDF]
Liu D, Zhao J, Lu M, Wang Z, He J.
europepmc +1 more source
This work reports the in situ fabrication of Escherichia coli@covalent organic frameworks (E. coli@COFs) in phosphate‐buffered saline. The COFs form an exoskeleton on E. coli, protecting intracellular β‐glucosidase (Ssbgl) while enhancing mass transfer.
Fengmei Liu +6 more
wiley +1 more source
Analysis of Rutting Formation Mechanisms and Influencing Factors in Asphalt Pavements Under Slow-Moving Heavy Loads. [PDF]
Li P, Fu J, Sun L, Yue J, Zang Q.
europepmc +1 more source
The phosphite group endows intrinsic flame retardancy, while the P = O bond enhances intermolecular interactions to realize solid‐solid phase transition. Battery thermal management tests show the materials extend the safe working time of lithium‐ion batteries by 200%. Cone calorimeter tests indicate a 14s delay in ignition time, and reductions of 37.6%,
Changhui Liu +9 more
wiley +1 more source
Comprehensive image dataset of flexible pavement: Alligator cracks and edge-breaks from national highway (N6) of urban areas. [PDF]
Hossain MN +5 more
europepmc +1 more source
Programmable Topological Magnetic Textures in Above‐Room‐Temperature 2D Ferromagnet Fe3GaTe2
This work demonstrates the programmable generation and deterministic modulation of magnetic skyrmion bags with high‐order topological numbers in the above‐room‐temperature 2D ferromagnet Fe3GaTe2 (FGaT) via current‐pulse control. Furthermore, highly efficient electrical manipulation and current‐driven parallel motion of these high‐order topological ...
Hanqing Shi +8 more
wiley +1 more source
Micro-Energy Harvesting and Self-Powered Sensing for Intelligent Road: A Comprehensive Review. [PDF]
Zheng G +5 more
europepmc +1 more source

