Results 31 to 40 of about 7,206 (137)

HIV-Tat-mediated Bcl-XL delivery protects retinal ganglion cells during experimental autoimmune optic neuritis

Neurobiology of Disease, 2005
In multiple sclerosis (MS), post-mortem studies of human brain tissue as well as data from animal models have shown that apoptosis of neurons occurs to a significant extent during this disease.
Ricarda Diem, Naimeh Taheri, Gunnar P.H. Dietz, Antje Kuhnert, Katharina Maier, Muriel B. Sättler, Ivana Gadjanski, Doron Merkler, Mathias Bähr   +8 more
doaj   +1 more source

Canonical and non‐canonical functions of proteins regulating mitochondrial dynamics in mammalian physiology

The Journal of Physiology, EarlyView.
Abstract figure legend Mitochondria are highly dynamic organelles that continuously remodel their architecture through coordinated cycles of fusion and fission. This review examines the four key GTPases that orchestrate mitochondrial dynamics in mammals: MFN1, MFN2, OPA1, and DRP1.
Rémi Chaney, Vincent Marcangeli, Krystel Desjardins, Shima Taherkhani, Gilles Gouspillou   +4 more
wiley   +1 more source

Further efforts needed to achieve measles elimination in Germany: results of an outbreak investigation

Bulletin of the World Health Organization, 2009
OBJECTIVE: To determine morbidity and costs related to a large measles outbreak in Germany and to identify ways to improve the country's national measles elimination strategy.
Ole Wichmann, Anette Siedler, Daniel Sagebiel, Wiebke Hellenbrand, Sabine Santibanez, Annette Mankertz, Georg Vogt, Ulrich van Treeck, Gérard Krause   +8 more
doaj  

Temporal trends in mortality due to coronary heart disease in Germany from 1998 to 2023 [PDF]

Journal of Health Monitoring
Background: Coronary heart disease (CHD) is the leading cause of death in Germany. Comprehensive analyses of long-term trends in CHD mortality that also distinguish between acute myocardial infarction (AMI) and non-AMI-related chronic CHD are currently ...
Henriette Steppuhn, Jens Baumert, Viktoria Rücker, Kai Günther, Annelene Wengler, Fabian Tetzlaff, Hannelore Neuhauser   +6 more
doaj   +1 more source

Tonotopically distinct OFF responses arise in the mouse auditory midbrain following sideband suppression

The Journal of Physiology, EarlyView.
Abstract figure legend Sounds of different frequencies elicit spatially distinct patterns of neural activity within the inferior colliculus aligned to the tonotopic organization of afferent projections. Sound‐evoked neural responses can be visualized in awake mice that express fluorescent Ca2+ sensors.
Patrick D. Parker, Amanda M. Lauer, Dwight E. Bergles   +2 more
wiley   +1 more source

Profiling for Bioactive Peptides and Volatiles of Plant Growth Promoting Strains of the Bacillus subtilis Complex of Industrial Relevance

Frontiers in Microbiology, 2020
Plant growth promoting rhizobacteria attain increasing importance in agriculture as biofertilizers and biocontrol agents. These properties significantly depend on the formation of bioactive compounds produced by such organisms.
Pascal Mülner, Pascal Mülner, Elisa Schwarz, Kristin Dietel, Helmut Junge, Stefanie Herfort, Max Weydmann, Peter Lasch, Tomislav Cernava, Gabriele Berg, Joachim Vater, Joachim Vater   +11 more
doaj   +1 more source

The African Network for Improved Diagnostics, Epidemiology and Management of common infectious Agents

BMC Infectious Diseases, 2021
Background In sub-Saharan Africa, acute respiratory infections (ARI), acute gastrointestinal infections (GI) and acute febrile disease of unknown cause (AFDUC) have a large disease burden, especially among children, while respective aetiologies often ...
Grit Schubert, Vincent Achi, Steve Ahuka, Essia Belarbi, Ouattara Bourhaima, Tim Eckmanns, Siobhan Johnstone, Firmin Kabore, Ouffoue Kra, Adriano Mendes, Abdoul-Salam Ouedraogo, Armel Poda, Arsène Satouro Some, Sara Tomczyk, Emmanuel Couacy-Hymann, Jean-Marie Kayembe, Nicolas Meda, Jean-Jacques Muyembe Tamfum, Soumeya Ouangraoua, Nicola Page, Marietjie Venter, Fabian H. Leendertz, Chantal Akoua-Koffi, the ANDEMIA consortium   +23 more
doaj   +1 more source

Reductive Methylation: An Alternative to Lysine → Arginine Mutagenesis

Journal of Peptide Science, Volume 32, Issue 7, July 2026.
Replacing lysine with arginine, the standard genetic approach to eliminate amine reactivity, alters physicochemical properties and leaves the N terminus unprotected. Here, reductive methylation is characterized as a conservative chemical alternative. Complete dimethylation of human ribonucleases preserves thermostability, protein–protein interaction ...
Oscar J. Molina, Clair S. Gutierrez, Jinyi Yang, Evans C. Wralstad, Ronald T. Raines   +4 more
wiley   +1 more source

Investigations on spatial heterogeneity of humus forms and natural regeneration of Larch (Larix decidua Mill.) and Swiss Stone Pine (Pinus cembra L.) in an alpine timberline ecotone (Upper Engadine, Central Alps, Switzerland) [PDF]

Geographica Helvetica
The north-west facing study area in the Upper Engadine (Central Alps, Switzerland) encompasses the whole timberline ecotone between 2200 m and 2400 m a.s.l..
B. Hiller, A. Müterthies, F.-L. Holtmeier, G. Broll   +3 more
doaj   +1 more source

A Cross‐Country Evaluation of Respiratory Syncytial Virus and Human Metapneumovirus Surveillance Systems: Identifying Gaps and Best Practices for Improved Disease Monitoring

Reviews in Medical Virology, Volume 36, Issue 4, July 2026.
ABSTRACT Respiratory syncytial virus (RSV) and human metapneumovirus (hMPV) are seasonal respiratory viruses that can cause severe outcomes, particularly in older adults; however, their burden remains under‐captured. The World Health Organisation (WHO) recommends expanding surveillance over pathogens, such as RSV and hMPV, through the Mosaic ...
Oliver Martyn, Jill Devos, Pierre Bourron, Dina AbouElwafa, Olivier Vitoux, Thierry Rigoine de Fougerolles   +5 more
wiley   +1 more source