Results 51 to 60 of about 4,724,591 (255)

Myogenic Fusogen‐Engineered Lipid Nanoparticles Enhance mRNA Delivery in Skeletal Muscle

open access: yesAdvanced Functional Materials, EarlyView.
This study reports a biomimetic strategy of engineering full‐length Myomaker, a muscle‐specific fusogen, into lipid nanoparticles (LNPs) to harness the native myoblast fusion capability for skeletal muscle mRNA delivery. The resulting Mymk‐LNPs enhance transfection in differentiating myocytes and enable Cre‐mediated reporter activation in injured ...
Fangyu Zhang   +18 more
wiley   +1 more source

La investigación ecológica de las comunidades locales

open access: yesEMPIRIA: Revista de Metodología de Ciencias Sociales, 2013
Los trabajos científicos e institucionales de Robert Park marcan uno de los períodos más sugerentes de la investigación sociológica. Park completa el giro empírico iniciado por la primera generación del departamento de sociología de la Universidad de ...
Emilio Martínez Gutiérrez
doaj  

A Holistic Platform Approach for Developing Robust Pulmonary mRNA Delivery: Integrating Novel Phenolic Acid‐Derived Ionizable Lipids and Device Engineering

open access: yesAdvanced Functional Materials, EarlyView.
An integrated pulmonary mRNA delivery platform combining novel biodegradable syringic acid‐derived ionizable lipids, design‐of‐experiments formulation optimization, and vibrating‐mesh nebulizer engineering enabled stable aerosolization and efficient lung delivery.
Neha Kaushal   +21 more
wiley   +1 more source

Photo‐Degradable Polyester Networks and Multi‐Photon Printed Objects Based on Cyclic Ketene Acetals

open access: yesAdvanced Functional Materials, EarlyView.
The current work introduces a photoreversible polyester network derived from radical ring‐opening polymerization of cyclic ketene acetals. It combines photoreversible cross‐linking with initiator‐free multi‐photon printing. Reversible network formation, tunable mechanical properties, and selective degradation highlight its potential as a versatile ...
Till Meissner   +5 more
wiley   +1 more source

Operações no Espaço, Operações na Memória: Uma análise do Welcome Park, de Venturi, Scott-Brown & Rauch, na Filadélfia

open access: yesarq.urb, 2015
Este trabalho apresenta um estudo do Welcome Park, uma espécie de memorial projetado pelo escritório norte-americano de Robert Venturi, Denise Scott-Brown e John Rauch.
Fernando Atique
doaj  

Protein‐Nanoarchitectures for Low‐Field Intracellular Electro‐Immunomodulation

open access: yesAdvanced Functional Materials, EarlyView.
DHQ‐SDH‐mediated binding of AuNPs drives the formation of interconnected, chain‐like nanoarchitectures with enhanced electrical conductivity. These conductive assemblies undergo macrophage uptake and enable low‐field electrical stimulation, promoting M1‐to‐M2 phenotypic switching with decreased iNOS and increased CD206 expression. Such protein‐mediated
Viktoriya Pakharenko   +7 more
wiley   +1 more source

Unique Role of Microstructure of a Bioimplant Zinc Alloy and Protein Content of Simulated Body Fluid in Corrosion and Fracture

open access: yesAdvanced Functional Materials, EarlyView.
BSA addition to physiological solutions enhances resistance of a Zn alloy to stress corrosion cracking (SCC) but reduces its corrosion resistance. Extended surface characterization explains the contrasting influences on corrosion and SCC. Unexpectedly, the alloy suffers transgranular SCC (TGSCC), despite extensive grain boundary precipitation. Thorough
RK Singh Raman   +9 more
wiley   +1 more source

Lightweight Solution to Generate Accurate Lanelet Maps

open access: yesEngineering Proceedings
As automated driving technologies become more mature, there is an increasing reliance on digital maps to support safe and efficient driving. Sensors like cameras and radars can be limited by occlusions, lighting conditions, or weather, and often fall ...
Gergő Ignéczi   +2 more
doaj   +1 more source

Robert geranium flower, probably in Olympic National Park, date unknown

open access: yes, 1881
Herb Robert; Geranium robertianum.
Unknown
core  

Engineered Microvascular Model of the Blood–Brain–Tumor Barrier Reveals Endothelial Remodeling in Diffuse Midline Glioma

open access: yesAdvanced Healthcare Materials, EarlyView.
We developed a patient‐derived, functional microfluidic model of the diffuse midline glioma (DMG) blood–brain–tumor barrier (BBTB) comprised of endothelial cells, astrocytes, pericytes, and tumor cells. The system forms perfusable microvasculature, reveals the BBTB retains vascular integrity, identifies DMG‐specific transcriptomic changes distinct from
Kimberly R. Bennett   +7 more
wiley   +1 more source

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