Results 111 to 120 of about 167 (164)

A Simple and Efficient Stereoselective Synthesis of a 2,3‐Difluorosialic Acid‐Based Influenza Virus Neuraminidase Inhibitor

Chemistry – A European Journal, Volume 31, Issue 16, March 17, 2025.
A new simple approach for the exquisitely stereo‐controlled introduction of the C‐3 equatorial fluorine on neuraminic acid derivatives by incorporation of steric bulk at C‐4. Through this size‐controlled method, we have elaborated a novel synthetic route that exclusively produces the potent anti‐influenza drug candidate; 2,3‐difluoro‐zanamivir analogue
Ibrahim M. El‐Deeb, Mark von Itzstein
wiley   +1 more source

Phosphorus‐Nitrogen Heterocycles Derived from Chelating N‐Donor Ligands: Historical Advances, Recent Highlights, and Outlook

Chemistry – A European Journal, Volume 31, Issue 16, March 17, 2025.
The chemistry of PN heterocycles is underexplored relative to systems based on main group atoms such as boron. However, strategies for their production have been developed. As a result, the application of PN heterocycles as functional molecular materials, in small molecule activation chemistry and catalysis, and bioimaging and therapeutics have emerged.
Shrabani Khan, Joe B. Gilroy
wiley   +1 more source

Functionalization, Fragmentation, and Expansion of cyclo‐P4R2 Ligands

Chemistry – A European Journal, EarlyView.
Three isolobal transition metal (TM) units are demonstrated to impact the transformation of coordinated P4 ligands in different ways. The observed reactivity primarily depends on the nature of the TM, an effect so far underexplored in phosphorus chemistry. This in‐depth analysis shines light on the underlying mechanistic principles and exploits them to
Christoph Riesinger, Lisa Zimmermann, Robert Szlosek, Gábor Balázs, Jan Wieneke, Lisa‐Marie Orel, Luis Dütsch, Manfred Scheer   +7 more
wiley   +1 more source

Synthesis and Reactivity of Triphosphaallyl Cation stabilized by N‐Heterocyclic Carbenes

Chemistry – A European Journal, Accepted Article.
Reduction of the triphosphaallyl species 6[GaCl4] with GaI[Ga2Cl7] affords the imidazoliumyl‐substituted (L) bicyclo[2.1.1]‐triphosphane, 10[Ga2Cl7], featuring an unprecedented Ga2Cl5‐bridged P3 scaffold. Reactions of 10[Ga2Cl7] with nucleophiles (Cl‐ or NHC) result in rare, selective P–C bond cleavages, affording Ga2Cly‐substituted triphosphiranes ...
Julia Frötschel-Rittmeyer, Felix Hennersdorf, Jannis Fidelius, Chris Sala, Christoph Ziegler, Michael Holthausen, Kai Schwedtmann, Robert Wolf, Jan J. Weigand   +8 more
wiley   +1 more source

Effect of NaOH Steam on Swelling and Cleaning of Food Soil Layers

Chemie Ingenieur Technik, EarlyView.
The effects of steam and NaOH steam, in comparison with water and sodium hydroxide, on the swelling behavior and removal forces of three food‐based soils were investigated. Comparative cleaning experiments were performed using these food soils after pre‐swelling with NaOH steam, steam, NaOH, or water.
Enrico Fuchs, Siegfried Beckmann, Robin Klusch, Marc Mauermann   +3 more
wiley   +1 more source

Optimal control of axial dispersion tubular reactors with recycle: Addressing state‐delay through transport PDEs

The Canadian Journal of Chemical Engineering, EarlyView.
The boundary‐regulated distributed parameter system of an axial dispersion tubular reactor with delayed recycle is showcased, along with the optimal observer‐based control strategy developed using a late‐lumping method for its stabilization. Abstract The optimal control of an axial tubular reactor with a recycle stream is addressed as a key type of ...
Behrad Moadeli, Guilherme Ozorio Cassol, Stevan Dubljevic   +2 more
wiley   +1 more source

Noisy matrix completion for longitudinal data with subject‐ and time‐specific covariates

Canadian Journal of Statistics, EarlyView.
Abstract In this article, we consider the imputation of missing responses in a longitudinal dataset via matrix completion. We propose a fixed‐effect, longitudinal, low‐rank model that incorporates both subject‐specific and time‐specific covariates. To solve the optimization problem, a two‐step optimization algorithm is proposed, which provides good ...
Zhaohan Sun, Yeying Zhu, Joel A. Dubin
wiley   +1 more source

Small‐Molecule KRAS Inhibitors by Tyrosine Covalent Bond Formation

ChemMedChem, EarlyView.
Small molecules form a covalent bond at KRAS tyrosine and inhibit its activation by guanine exchange factors in biochemical assays and mammalian cells. The development of the KRAS G12C inhibitor sotorasib is a major advance toward drugging KRAS. However, the G12C mutation is only found in about 10% of KRAS‐driven tumors. KRAS possesses several tyrosine
Alexander D. Landgraf, Robert Brenner, Mona K. Ghozayel, Khuchtumur Bum‐Erdene, Giovanni Gonzalez‐Gutierrez, Samy O. Meroueh   +5 more
wiley   +1 more source

Hybrid Molecules as Efficient Drugs against Multidrug‐Resistant Malaria Parasites

ChemMedChem, EarlyView.
Among hybrid molecules currently developed as antimalarial drug candidates, emoquine‐1 exhibits high activity against all the multidrug‐resistant Plasmodium strains tested up to now, including artemisinin‐resistant quiescent parasites, critical parameters for promising antimalarial drugs. It is also curative in mouse malaria.
Anne Robert, Lucie Paloque, Jean‐Michel Augereau, Flore Nardella, Michel Nguyen, Bernard Meunier, Françoise Benoit‐Vical   +6 more
wiley   +1 more source

The Zr8O6 Secondary Building Unit and Porphyrin Linker Catalyze Light‐Driven H2 Evolution in Porphyrin‐Based Metal Organic Frameworks

ChemSusChem, EarlyView.
Zr8O6‐based metal–organic frameworks (porous coordination network PCN 221 M, M = 2 H, Zn, Ni, ZnNi) with metalloporphyrin linkers are explored for H2 evolution under 405 nm light emitting diode irradiation. PCN 221 Zn exhibits the highest activity with a turnover number (TON) of 4 via dual charge transfer pathways. Spectroscopy revealed Zn‐TCPP acts as
Subrata Mandal, Robert Leiter, Johannes Biskupek, Ute Kaiser, Andrea Pannwitz   +4 more
wiley   +1 more source