Results 141 to 150 of about 2,612 (214)

Small‐Molecule KRAS Inhibitors by Tyrosine Covalent Bond Formation

ChemMedChem, Volume 20, Issue 12, June 17, 2025.
Small molecules form a covalent bond at KRAS tyrosine and inhibit its activation by guanine exchange factors in biochemical assays and mammalian cells. The development of the KRAS G12C inhibitor sotorasib is a major advance toward drugging KRAS. However, the G12C mutation is only found in about 10% of KRAS‐driven tumors. KRAS possesses several tyrosine
Alexander D. Landgraf, Robert Brenner, Mona K. Ghozayel, Khuchtumur Bum‐Erdene, Giovanni Gonzalez‐Gutierrez, Samy O. Meroueh   +5 more
wiley   +1 more source

Importance of Considering Temporal Variations in Pulse Wave Velocity for Accurate Blood Pressure Prediction. [PDF]

Ann Biomed Eng
Bantwal AS, Bhayadia AK, Meng H.
europepmc   +1 more source

The Zr8O6 Secondary Building Unit and Porphyrin Linker Catalyze Light‐Driven H2 Evolution in Porphyrin‐Based Metal Organic Frameworks

ChemSusChem, EarlyView.
Zr8O6‐based metal–organic frameworks (porous coordination network PCN 221 M, M = 2 H, Zn, Ni, ZnNi) with metalloporphyrin linkers are explored for H2 evolution under 405 nm light emitting diode irradiation. PCN 221 Zn exhibits the highest activity with a turnover number (TON) of 4 via dual charge transfer pathways. Spectroscopy revealed Zn‐TCPP acts as
Subrata Mandal, Robert Leiter, Johannes Biskupek, Ute Kaiser, Andrea Pannwitz   +4 more
wiley   +1 more source

Effective Behaviour of Critical-Contrast PDEs: Micro-Resonances, Frequency Conversion, and Time Dispersive Properties. II. [PDF]

Commun Math Phys
Cherednichenko K, Kiselev AV, Velčić I, Žubrinić J.   +3 more
europepmc   +1 more source

Upcycling of Waste Poly(ethylene terephthalate) : Ammonolysis Kinetics of Model Bis(2‐hydroxyethyl terephthalate) and Particle Size Effects in Polymeric Substrates

ChemSusChem, Accepted Article.
Upcycling of poly(ethylene terephthalate) (PET) through ammonolysis is pursued. Model studies on bis(2‐hydroxyethyl) terephthalate (BHET) reacting with ammonia in excess ethylene glycol (EG) to form terephthalamide (TPD) are presented. Sequential ester conversion is characterized by the pseudo reaction rate constants of = 1.02±0.09 h‐1 and = 0.44±0.08 ...
Richard-Joseph L. Peterson, Elanna P. Neppel, Daniel Holmes, Robert Ofoli, John R. Dorgan   +4 more
wiley   +1 more source

Resolving elliptic boundary value problem and integral equation in relational partial metric space. [PDF]

Heliyon
Joshi M, Tomar A, Sajid M, Padaliya SK.
europepmc   +1 more source

Monolithically Integrated Quantum Dots in a 22‐nm Fully Depleted Silicon‐on‐Insulator Process Operating at 3 K

International Journal of Circuit Theory and Applications, EarlyView.
In this paper, we describe the complete architecture for quantum control and read‐out of charge qubits designed in 22‐nm FD‐SOI process. Detail system level analysis is provided along with lab measurement results at 3 K for cryogenic control and for a quantum dot array.
Imran Bashir, Andrii Sokolov, Xutong Wu, Panagiotis Giounanlis, Nikolaos Petropoulos, Dirk Leipold, Mike Asker, Ali Esmailiyan, Dennis Andrade‐Miceli, Hans‐Christoph Haenlein, Conor McGeough, Robert Bogdan Staszewski, Elena Blokhina   +12 more
wiley   +1 more source

The role of recharge/discharge and hydraulic conductivity in gravitational groundwater flow systems. [PDF]

Sci Rep
Baalousha HM.
europepmc   +1 more source

Electrical Conductivities and Low Frequency Opacities in the Warm Dense Matter Regime

Contributions to Plasma Physics, EarlyView.
ABSTRACT In this article, we examine different approaches for calculating low frequency opacities in the warm dense matter regime. The relevance of the average‐atom approximation and of different models for calculating opacities, such as the Ziman or Ziman–Evans models is discussed and the results compared to ab initio simulations.
Mikael Tacu, Jean‐Christophe Pain, Matthias Pautard, Christophe Blancard   +3 more
wiley   +1 more source

Fine-Grained Boundary Conditions in Field-Based Routing. [PDF]

Sensors (Basel)
Sung J, Kyung Y.
europepmc   +1 more source