Results 161 to 170 of about 109,310 (329)

A Murine Bispecific Antibody Efficiently Redirects T Cells Against Calr Mutated Stem Cells In Vivo

open access: yesAmerican Journal of Hematology, EarlyView.
ABSTRACT Calreticulin (CALR) mutations are prevalent in 20%–30% of patients with BCR::ABL1‐negative myeloproliferative neoplasms (MPN). Mutant calreticulin (mutCALR), presented by the thrombopoietin receptor (MPL, also known as TPOR or CD110) on the surface of the disease‐initiating MPN progenitors, represents an ideal target for curative ...
Shengen Xiong   +5 more
wiley   +1 more source

Recombinant Human Neuregulin1‐β1 Significantly Reduces Schwannoma Growth in Mice

open access: yesAnnals of Neurology, EarlyView.
rhNRGβ1‐Replacement‐Therapy: Under physiological conditions, NRGβ1 is expressed on axons (in orange), where it activates ERBB2 receptors, facilitating successful nerve regeneration following injury. However, loss of NF2 leads to a reduction in NRGβ1‐expression and increased ErbB2 levels on Schwann cells (in green), which contributes to schwannoma ...
Julia P. Bischoff   +7 more
wiley   +1 more source

Individualized Atrophy‐Based Prediction of Dementia Progression in Familial Frontotemporal Lobar Degeneration With Bayesian Linear Mixed‐Effects Modeling

open access: yesAnnals of Neurology, EarlyView.
Objective Age of symptom onset is highly variable in familial frontotemporal lobar degeneration (f‐FTLD). Accurate prediction of onset would inform clinical management and trial enrollment. Prior studies indicate that individualized maps of brain atrophy can predict conversion to dementia in f‐FTLD.
Shubir Dutt   +82 more
wiley   +1 more source

Entropy solutions for nonlinear elliptic anisotropic problem with Robin boundary condition

open access: yesLe Matematiche, 2013
We study a Robin boundary value problem of nonlinear elliptic anisotropic type. We prove the existence and uniqueness of entropy solutions for $L^{1}$-data, via the existence and uniqueness of weak solution.
Stanislas Ouaro   +2 more
doaj  

Robin boundary conditions in shape optimization

open access: yes, 2015
The present thesis is concerned with the problem of proving the existence of optimal domains for functionals subjected to Robin Boundary conditions. We treat both cases of positive and negative Robin parameters. In the case of positive Robin parameters we prove the existence of a minimizing domain in a class of Lipschitz domains of given measure, that ...
openaire   +1 more source

Combinatorial SiO2‐Encapsulated Quantum Dot Nanoparticles and their Use in Spectral Unmixing Analysis

open access: yesAnalysis &Sensing, EarlyView.
Combinatorial QD‐SiO2 nanoparticles combined with linear unmixing of the photoluminescence spectrum increase the multiplexity of assays. Linear unmixing spectral analysis is a technique where signals from tens of fluorophores can be deconvoluted to increase multiplexing by 4–5‐fold.
Yuwei Wang, Jennifer I. L. Chen
wiley   +1 more source

On some nonlinear potential problems

open access: yesElectronic Journal of Differential Equations, 1999
The degree theory of mappings is applied to a two-dimensional semilinear elliptic problem with the Laplacian as principal part subject to a nonlinear boundary condition of Robin type. Under some growth conditions we obtain existence.
M. A. Efendiev   +2 more
doaj  

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