Human Dental Pulp Stem Cell Secretome Restores Ischemic Stroke-Impaired Motor and Cognitive Functions by Reprogramming Redox and Inflammatory Signaling. [PDF]
Adv Sci (Weinh)Human dental pulp stem cell secretome emerges as a cell‐free therapeutic strategy for ischemic stroke by reprogramming redox and inflammatory signaling. hDPSC secretome‐derived antioxidant and immunomodulatory factors suppress the TLR4–NOX–ROS–NF‐κB axis, reduce microglial inflammatory responses and apoptosis, and promote neurogenesis, angiogenesis ...
Seong KJ +8 more
europepmc +2 more sources
Deconstruction of Human Age-Related Cataract Capsules Defines Aging. [PDF]
Adv Sci (Weinh)We generate a comprehensive atlas of age‐related cataracts (ARC) at a single‐cell resolution, encompassing three disease states—mild cataract group (Mild), severe cortical cataract group (Severe_C), and severe nuclear cataract group (Severe_N). We find that ARC involves seven distinct lens capsule cell types, with notable differences in cellular ...
Tang Q +9 more
europepmc +2 more sources
Endothelial Slit2 guides the Robo1-positive sympathetic innervation during heart development [PDF]
eLifeAxon guidance cues direct nerves in the heart during development, disease, and regeneration. These cues determine cardiac innervation patterning by regulating the balance between chemo-attraction and chemo-repulsion.
Juanjuan Zhao +7 more
doaj +2 more sources
Slit2/Robo Signaling Restores Diabetic Erectile Function via Neurovascular Remodeling. [PDF]
AndrologyABSTRACT Background Diabetes mellitus‐induced erectile dysfunction (DMED) is a common and debilitating vascular‐neurogenic complication of diabetes. The poor responsiveness of DMED patients to phosphodiesterase type‐5 inhibitors underscores the need for therapies capable of restoring both endothelial integrity and cavernous nerve function.
Fu S +7 more
europepmc +2 more sources
ROBO-SPOT: Detecting Robocalls by Understanding User Engagement and Connectivity Graph
Robo or unsolicited calls have become a persistent issue in telecommunication networks, posing significant challenges to individuals, businesses, and regulatory authorities.
Junaid Arshad (3761089) +2 more
core +9 more sources
Robo-Advisors: Automated advisory in the stock market [PDF]
, 2020 Con el fin de contribuir en la comprensión de las transformaciones que enfrenta la actividad de asesoría financiera en un entorno digital, AMV y la Universidad del Rosario presentan este documento, que se divide en seis partes, así: en la primera, se ...
Cano, Jeimy J. +1 more
core +1 more source
Revista Criminalidad, 2018 Este artículo tiene como objetivos: i) describir las rutas de circulación de computadoras portátiles robadas, en cuatro mercados del centro de Lima; ii) analizar los factores que inciden en la transformación del precio de las computadoras portátiles ...
Jaris Mujica +2 more
doaj +3 more sources
The expression pattern of EVA1C, a novel Slit receptor, is consistent with an axon guidance role in the mouse nervous system. [PDF]
PLoS ONE, 2013 The Slit/Robo axon guidance families play a vital role in the formation of neural circuitry within select regions of the developing mouse nervous system. Typically Slits signal through the Robo receptors, however they also have Robo-independent functions.
Gregory James +3 more
doaj +1 more source
Características del proceso penal en el delito de robo agravado del expediente N° 2450-2016-68-2402-JR-PE-01; Cuarto Juzgado de Investigación Preparatoria, Coronel Portillo distrito judicial del Ucayali - Perú, 2019 [PDF]
, 2022 El trabajo de investigación tuvo como objetivo general, Determinar las características del proceso penal en el delito de robo agravado del expediente N° 2450-2016-68- 2402-JR-PE-01; Cuarto Juzgado De Investigación Preparatoria, Coronel
Ramos Pinedo, Jesus Alberto
core