Results 241 to 250 of about 782,515 (314)

Identification of CD38high Monocyte as a Candidate Diagnostic Biomarker and Therapeutic Target for Sepsis

Advanced Science, EarlyView.
This study uncovers that CD38high monocytes discriminate sepsis and sterile inflammation and are associated with 28‐day mortality in bacterial sepsis. Targeting CD38 therapy reduces inflammatory response in monocytes and in sepsis mice model. Mechanistically, CD38‐HIF‐1α/glycolysis/MGO loop exacerbates sepsis‐induced immune dysregulation.
Ning Hua, Limin Kong, Li Fan, Yanan Bai, Yujun Zhou, Yanfang Zhang, Qingwei Zhao, Xiaoyang Lu, Hongyu Yang, Hangyang Li, Peili Ding, Yuyu Nan, Qinghua Ji, Ping Yang, Lu Li, Yijing Xin, Lijuan Zhao, Wei Yang, Wenqiao Yu, Saiping Jiang   +19 more
wiley   +1 more source

The effect of blood glucose and lipid risk factors on idiopathic sudden sensorineural hearing loss: A two-sample Mendelian randomization study. [PDF]

Braz J Otorhinolaryngol
Deng BY, Zhao YX, Liu JS.
europepmc   +1 more source

Photonic Bayesian Neural Networks: Leveraging Programmable Noise for Robust and Uncertainty‐Aware Computing

Advanced Science, EarlyView.
This work introduces a novel photonic Bayesian neural network architecture that utilizes tunable photonic random number generators to independently control weight distribution parameters, significantly improving robustness, scalability, and accuracy while demonstrating practical applications in multimodal data processing and uncertainty‐aware computing.
Yangyang Zhuge, Zhihao Ren, Zian Xiao, Zixuan Zhang, Xinmiao Liu, Weixin Liu, Siyu Xu, Chong Pei Ho, Nanxi Li, Chengkuo Lee   +9 more
wiley   +1 more source

Exploring the Relationship between Caffeine Consumption, Caffeine Metabolism, and Sleep Behaviours: A Mendelian Randomisation Study

Das NR, Woolf B, Page S, Richmond RC, Khouja J.   +4 more
europepmc   +1 more source

Plasma DNMT1 Activity for Assessing Tumor Burden and Predicting Neoadjuvant Therapy Response in Breast Cancer

Advanced Science, EarlyView.
In this work, a detection method is presented for the activity of plasma DNA methyltransferase 1 (DNMT1), namely DNMT1 Identification by Variable Activity (DIVA). DIVA can detect plasma DNMT1 at levels as low as 10−7 U mL−1, also it successfully evaluated tumor burden and predicted the neoadjuvant therapy responses of breast cancer patients.
Yingran Wang, Guozhi Zhang, Zhizhao Zhang, Mengsi Zhang, Jiao Chen, Ke Wang, Lu Liu, Jing Bao, Ming Chen, Xiaowei Qi, Mingxuan Gao   +10 more
wiley   +1 more source

Is there a competitive advantage to using multivariate statistical or machine learning methods over the Bross formula in the hdPS framework for bias and variance estimation? [PDF]

PLoS One
Ehsanul Karim M, Lei Y.
europepmc   +1 more source

Nanogenerator Neuromodulation to Enable Locomotion Rehabilitation for Spinal Cord Injury via Epidural Electrical Stimulation

Advanced Science, EarlyView.
A hybrid nanogenerator (H‐NG) has been developed to be applied in epidural electrical stimulation (EES). Compared with a commercial stimulus generator (SG), the H‐NG can elicit hindlimb locomotion in rats with much lower electrical parameters and much smaller individual differences.
Cong Li, Yizhu Shan, Shihao Zheng, Puchuan Tan, Yuan Bai, Engui Wang, Lingling Xu, Ruizeng Luo, Shengyu Chao, Jing Huang, Pengyu Ren, Zhou Li, Hongqing Feng   +12 more
wiley   +1 more source

Dissecting the causal effects of smoking, alcohol consumption, and related DNA methylation markers on electrocardiographic indices. [PDF]

Clin Epigenetics
Zheng Z, Song Y, Li X, Luo T, Tan X.
europepmc   +1 more source

Testosterone Delays Bone Microstructural Destruction via Osteoblast‐Androgen Receptor‐Mediated Upregulation of Tenascin‐C

Advanced Science, EarlyView.
This study reveals that Testosterone–Androgen Receptor signaling delays elderly male bone destruction by upregulation of the osteoblastic extracellular tenascin‐C (TNC). The osteoprotective effect of fibrinogen C‐terminus of TNC is demonstrated in male osteoporotic mice model that osteoblast‐specific Ar‐knockout, potentially via inhibition of ...
Yong Xie, Meng Pan, Zeyuan Zhang, Licheng Zhang, Haotian Liu, Xia Wang, William W Lu, Peifu Tang, Wei Ge   +8 more
wiley   +1 more source

Low morphology does not lower success after intrauterine insemination unless inseminating motile sperm count is low. [PDF]

PLoS One
Burks H, Peck JD, Hansen KR, Stoner J, Craig LB.   +4 more
europepmc   +1 more source