Results 261 to 270 of about 1,304,981 (339)
This study uses single‐nucleus RNA sequencing and spatial transcriptomics to investigate penile squamous cell carcinoma (PSCC). It reveals that PSCC tumor cells mimic normal penile epithelium differentiation, independent of HPV status. The Tum_1 subtype shows basal stem‐like characteristics and promotes invasiveness. HPV‐positive basal stem‐like tumors
Hongjian Song+37 more
wiley +1 more source
Vascular clues in joint degeneration: a cross-sectional study on the association between aortic knob width, aortic arch calcification, and the severity of hand and knee osteoarthritis. [PDF]
Erden Y, Sağlam M, Temel MH.
europepmc +1 more source
We demonstrate that Foxp1± mice, modeling FOXP1 haploinsufficiency, exhibit behavioral deficits, striatal neuroinflammatory changes including altered microglial complexity and synaptic pruning, and markedly reduced Pde10a expression. Pde10a inhibition starting immediately after birth restores Foxp1± behavior, microglial morphology, and pruning ...
Henning Fröhlich+8 more
wiley +1 more source
Systematic Evaluation of Atrous Spatial Pyramid Pooling in U-Net for Pore Segmentation in Plasma Electrolytic Oxidation Coatings. [PDF]
Chu CW, Lu CM, Yeung WK.
europepmc +1 more source
In this work, a detection method is presented for the activity of plasma DNA methyltransferase 1 (DNMT1), namely DNMT1 Identification by Variable Activity (DIVA). DIVA can detect plasma DNMT1 at levels as low as 10−7 U mL−1, also it successfully evaluated tumor burden and predicted the neoadjuvant therapy responses of breast cancer patients.
Yingran Wang+10 more
wiley +1 more source
Response to commentary on "pembrolizumab in gestational trophoblastic neoplasia: systematic review and meta-analysis with sub-group analysis of potential prognostic factors". [PDF]
Barcellos M+9 more
europepmc +1 more source
Chen et al. identified a metabolic gene prognostic signature with machine‐learning framework and assessed the prognostic value in independent CRC cohorts. The metabolic signature subtypes are characterized by specific metabolic and proteomic characteristics, and associated with distinct molecular pathway and therapeutic potential.
Hao Chen+12 more
wiley +1 more source
Charting the course of depression care: a meta-analysis of reliability generalization of the patient health questionnaire (PHQ- 9) as the measure. [PDF]
Ajele KW, Idemudia ES.
europepmc +1 more source
This study reveals that Testosterone–Androgen Receptor signaling delays elderly male bone destruction by upregulation of the osteoblastic extracellular tenascin‐C (TNC). The osteoprotective effect of fibrinogen C‐terminus of TNC is demonstrated in male osteoporotic mice model that osteoblast‐specific Ar‐knockout, potentially via inhibition of ...
Yong Xie+8 more
wiley +1 more source