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Molecular Oncology, Volume 19, Issue 6, Page 1811-1835, June 2025.Prostate cancer is a leading malignancy with significant clinical heterogeneity in men. An 11‐gene signature derived from dysregulated epithelial cell markers effectively predicted biochemical recurrence‐free survival in patients who underwent radical surgery or radiotherapy.
Zhuofan Mou, Lorna W. Harries
wiley +1 more source
Huber-Robust Confidence Sequences [PDF]
arXiv, 2023 Confidence sequences are confidence intervals that can be sequentially tracked, and are valid at arbitrary data-dependent stopping times. This paper presents confidence sequences for a univariate mean of an unknown distribution with a known upper bound on the $p$-th central moment ($p$ > 1), but allowing for (at most) $\epsilon$ fraction of arbitrary ...
arxiv
Molecular Oncology, EarlyView.Presurgery 72‐h fasting in GB patients leads to adaptations of plasma lipids and polar metabolites. Fasting reduces lysophosphatidylcholines and increases free fatty acids, shifts triglycerides toward long‐chain TGs and increases branched‐chain amino acids, alpha aminobutyric acid, and uric acid.
Iris Divé +7 more
wiley +1 more source
Nonparametric evaluation of quantitative traits in population-based association studies when the genetic model is unknown. [PDF]
PLoS ONE, 2012 Statistical association between a single nucleotide polymorphism (SNP) genotype and a quantitative trait in genome-wide association studies is usually assessed using a linear regression model, or, in the case of non-normally distributed trait values ...
Frank Konietschke +2 more
doaj +1 more source
Globally robust confidence intervals for simple linear regression [PDF]
Computational Statistics & Data Analysis, 2010 It is well known that when the data may contain outliers or other departures from the assumed model, classical inference methods can be seriously affected and yield confidence levels much lower than the nominal ones. This paper proposes robust confidence intervals and tests for the parameters of the simple linear regression model that maintain their ...
Matias Salibian-Barrera +1 more
openaire +2 more sources
Robust estimation based on one-shot device test data under log-normal lifetimes [PDF]
arXiv, 2022 In this paper we present robust estimators for one-shot device test data under lognormal lifetimes. Based on these estimators, confidence intervals and Wald-type tests are also developed. Their robustness feature is illustrated through a simulation study and two numerical examples.
arxiv
Molecular Oncology, EarlyView.Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim +8 more
wiley +1 more source
Robust Learning from Bites for Data Mining [PDF]
, 2006 Some methods from statistical machine learning and from robust statistics have two drawbacks. Firstly, they are computer-intensive such that they can hardly be used for massive data sets, say with millions of data points.
Christmann, Andreas +2 more
core +2 more sources
Confidence intervals for average success probabilities [PDF]
, 2014 We provide Buehler-optimal one-sided and some valid two-sided confidence intervals for the average success probability of a possibly inhomogeneous fixed length Bernoulli chain, based on the number of observed successes.
Mattner, Lutz, Tasto, Christoph
core
Molecular Oncology, EarlyView.Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka +10 more
wiley +1 more source