Results 151 to 160 of about 11,839,721 (284)

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Robust design of LAMP assays for in-field detection of major bacterial vascular diseases of banana. [PDF]

PLoS One
Robène I, Arrieta-Salgado M, Rozsasi S, Mostert D, Maillot-Lebon V, Chilin-Charles Y, Jansen van Vuuren J, Nakato GV, Kanaabi R, Magdama F, Paredes Salgado E, Hermanto C, Sutanto A, Conie J, Henry D, Le Roux S, Viljoen A, Jouen E, Gauche M, Poussier S, Wicker E, Pecrix Y.   +21 more
europepmc   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Robust design of bicycle infrastructure networks. [PDF]

Sci Rep
Steinacker C, Paulsen M, Schröder M, Rich J.   +3 more
europepmc   +1 more source

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

Molecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen, Zhi Zhao, Henrik Horndalsveen, Maria Moksnes Bjaanæs, Bjørn Henning Grønberg, Tarje Halvorsen, Tesfaye Madebo, Marianne Aanerud, Jussi Koivunen, Kersti Oselin, Saulius Cicenas, Nina Helbekkmo, Jarkko Ahvonen, Maria Silvoniemi, Tine Norman Alver, Tonje Dalen, Åsa Kristina Öjlert, Saima Jamil Farooqi, Åslaug Helland, Vilde Drageset Haakensen   +19 more
wiley   +1 more source

Architecturally robust design of ethylenediamine-assisted polyaniline/MXene nanohybrids for symmetric pouch-cell supercapacitors. [PDF]

Nanoscale Adv
Radhakrishnan S, Mohapatra S, Anagha PS, Shibu A, Namsheer K, Pathak M, Jeong SM, Rout CS.   +7 more
europepmc   +1 more source

Guidance on the Design for Structural Robustness

This JRC Technical Report presents scientific and technical background information to introduce the different aspects involved in providing robustness of structures. It is intended to bring together references and ongoing work on the subject as well as stimulate debate.
Andre, J., Anghileri, M., Belletti, B., Biondini, F., Caspeele, R., Demonceau, Jean-François, Izzuddin, B., Martinelli, P., Molkens, T., O'Connor, A., Parisi, F., Sio, J., Sousa, M.L., Thienpont, T.   +13 more
openaire   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Performance Portrait Method: Robust Design of Predictive Integral Controller. [PDF]

Biomimetics (Basel)
Huba M, Bistak P, Skrinarova J, Vrancic D.   +3 more
europepmc   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source