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Robust Optimal Metabolic Factories
Journal of Computational BiologyPerhaps the most fundamental model in synthetic and systems biology for inferring pathways in metabolic reaction networks is a metabolic factory: a system of reactions that starts from a set of source compounds and produces a set of target molecules, while conserving or not depleting intermediate metabolites. Finding a shortest factory-that minimizes a
Spencer Krieger, John Kececioglu
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Robustness of Robust Process Optimization
Quality Engineering, 2002[This abstract is based on the author's abstract.] Different strategies for robust process optimization have been used to solve the problem of unwanted variation in production processes, but a number of factors can influence the precision of the me..
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Robustness of optimally robust controllers
[1991 Proceedings] The Twenty-Third Southeastern Symposium on System Theory, 2002The largest robust stability radius gamma (P/sub 0/) of a system P/sub 0/ is defined as the radius of the largest ball B/sub max/ in the gap metric centered at P/sub 0/ which can be stabilized by one single controller. Any controller which stabilizes B/sub max/ is called an optimally robust controller of P/sub 0/.
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Robust simulation-optimization methodology
2009This contribution summarizes a methodology for simulation optimization assuming some simulation inputs are uncertain. This methodology integrates Taguchi’s worldview (distinguishing between decision and environmental inputs), metamodeling (either Response Surface Methodology or Kriging), and mathematical programming.
J. P. C. Kleijnen +2 more
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