Results 91 to 100 of about 1,990,709 (285)
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Robust Hessian Locally Linear Embedding Techniques for High-Dimensional Data
Algorithms, 2016 Recently manifold learning has received extensive interest in the community of pattern recognition. Despite their appealing properties, most manifold learning algorithms are not robust in practical applications.
Xianglei Xing, Sidan Du, Kejun Wang
doaj +1 more source
Rough histograms for robust statistics [PDF]
Proceedings 15th International Conference on Pattern Recognition. ICPR-2000, 2002 Applied statistics are widely used in pattern recognition and other computing applications to find the most likely value of a parameter. The use of classical empirical statistics is based upon assumption about normality of underlying density distribution of data.
Olivier Strauss +2 more
openaire +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
Sensors, 2018 Automated segmentation of planar and linear features of point clouds acquired from construction sites is essential for the automatic extraction of building construction elements such as columns, beams and slabs.
Reza Maalek +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Unmixing of Hyperspectral Data Using Robust Statistics-based NMF
, 2012 Mixed pixels are presented in hyperspectral images due to low spatial resolution of hyperspectral sensors. Spectral unmixing decomposes mixed pixels spectra into endmembers spectra and abundance fractions.
Ghassemian, Hassan, Rajabi, Roozbeh
core +1 more source