Results 31 to 40 of about 426,295 (219)

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

Integration of CURB-65 and CT Severity Score for Prognostic Prediction in Community-acquired Pneumonia

Thoracic Research and Practice
OBJECTIVE: This study compared confusion, urea, respiratory rate, blood pressure, age ≥65 years (CURB-65) and computed tomography severity score (CTSS) for predicting 30-day mortality, intensive care unit (ICU) admission, and length of hospital stay in ...
Ökkeş Gültekin, Orhan Özçekici, İnan Arslantaş   +2 more
doaj   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer

Molecular Oncology, EarlyView.
New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau, Daniel Pincher, Clifford Young, Nicholas Chappell, Noor A. Lokman, Parul Mittal, Leigh Donnellan, Martin K. Oehler, Doug A. Brooks, Peter Hoffmann   +9 more
wiley   +1 more source

The impact of leukocyte‐associated RNA retention on platelet RNA‐based cancer detection

Molecular Oncology, EarlyView.
Platelets carry RNA signals that may help detect cancer, but platelet samples can also retain RNA from white blood cells. We found that this retained white blood cell signal did not significantly affect machine learning cancer classification, suggesting that the cancer‐related RNA signal in platelets is largely independent of leukocyte‐associated RNA ...
Michał Sieczczyński, Krzysztof Pastuszak, Anna Samelak‐Czajka, Zuzanna Cemka, Paulina Jackowiak, Tomasz Stefaniak, Sylwia Łapińska‐Szumczyk, Jacek Jassem, Anna J. Żaczek, Matthew T. Rondina, Myron G. Best, Sjors G. J. G. In 't Veld, Anna Supernat   +12 more
wiley   +1 more source

Clinical validation of the scales of depression, neuroticism, somatization, personal anxiety and validity of the modified questionnaire for neurotic disorders

Обозрение психиатрии и медицинской психологии имени В.М. Бехтерева, 2021
The classical theory of tests, in the framework of which a questionnaire for neurotic disorders was created, does not meet the requirements of modern psychometrics.
L. I. Tsydzik
doaj   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

Possibilities of non-invasive diagnosis of diabetic peripheral polyneuropathy in children with type 1 diabetes

Zdorovʹe Rebenka
Background. Most diagnostic tests for diabetic peripheral polyneuropathy (DPNP) are not suitable for use in childhood, resulting in low diagnostic accuracy of this complication. Therefore, it is necessary to identify reliable and simple markers for early
Г.О. Леженко, М.С. Спільник   +1 more
doaj   +1 more source

Electrical Conductivity as an Indicator to Assess the Suitability of River Water for Recreational Use

Journal of Water and Environment Technology, 2023
Urban rivers flowing through cities are places of recreation and relaxation for citizens. However, these rivers are sometimes contaminated by Escherichia coli (E. coli). Therefore, the purpose of this study was to develop a simple
Hanna Horiguchi, Katsumi Shigemura, Madoka Kitakawa, Minato Nakazawa, Tatsuhiko Noyori, Motomu Inoue, Reo Onishi, Michika Moriwaki, Chisato Yoshimura, Mayumi Kobayashi, Toshinobu Suzaki   +10 more
doaj   +1 more source

Using cell‐free RNA to identify B‐ and T‐cell clonality for diagnosis and monitoring of B‐ and T‐cell neoplasms

FEBS Open Bio, EarlyView.
Using peripheral blood for determining B‐cell or T‐cell clonality is more reliable when we use cell‐free RNA (cfRNA) because cells release blood significantly more RNA than DNA. Next‐generation sequencing (NGS) of cfRNA allows us to evaluate fragment cfRNA and evaluate clonality reliably without the need for prior determination of the specific dominant
Adam Albitar, Sally Agersborg, Ahmed Charifa, Pooja Phull, Noa Biran, David Vesole, Harsh Parmar, Andrew Pecora, Andrew Ip, Andre Goy, David Siegel, Maher Albitar   +11 more
wiley   +1 more source