Results 231 to 240 of about 380,756 (310)

Deep Learning‐Powered Scalable Cancer Organ Chip for Cancer Precision Medicine

Advanced Science, EarlyView.
This scalable, low‐cost Organ Chip platform, made via injection molding, uses capillary pinning for hydrogel confinement and supports versatile tissue coculture and robust imaging. Deep learning enables label‐free, sensitive phenotypic analysis.
Yu‐Chieh Yuan, Beibei Xu, Jenna McCormack, XuHai Huang, Jingzhe Ma, Thomas Marshall, Yacong Sun, Hardeep Singh, Alyssa Fanelli, Gauri Kulkarni, Ji Hye Seo, Paige Gilbride, Bing Wei, Bo Wang, Yanyan Liu, Fei Ma, Lin Zhou, Shuyang Wang, Xiaohua Qian, Zhiyong Xie, Polina Golland, Longlong Si, Yu Shrike Zhang, Xin Xie, Haiqing Bai   +24 more
wiley   +1 more source

Study on the evolution and transport pattern of overburden fracture induced by mining in cave mines. [PDF]

Sci Rep
Zhang Y, Xu M, Kong D, Zuo Y, Wu G, Chen F, Zhou Y.   +6 more
europepmc   +1 more source

Alphaviral Capsid Proteins Inhibit Stress Granule Assembly via Competitive RNA Binding With G3BP1

Advanced Science, EarlyView.
Stress granules exert antiviral functions. This study illustrates a conserved function of alphaviral capsid proteins in modulating stress granules. Oligomerization mediated by a helical motif coupled with a positively charged intrinsically disordered region (IDR) directly competes with G3BP1 for RNA binding, thereby disrupting G3BP1‐RNA liquid–liquid ...
Yun Zhang, Yi Liu, Zhiying Yao, Haolong Lai, Xiaoxin Chen, Ziqiu Wang, Yiqiong Bao, Tingting Li, Xiaoming Zhou, Xiabin Chen, Peiguo Yang   +10 more
wiley   +1 more source

Analysis of dramatic bedding landslide on dynamic instability and disaster factors. [PDF]

Sci Rep
Zhou F, Lv Y, Masiko MK, Li C, Zhang X.
europepmc   +1 more source

OCTN2 Activates a Non‐Canonical Carnitine Metabolic Pathway to Promote MASH‐HCC Progression and Immunotherapy Resistance

Advanced Science, EarlyView.
In non‐MASH‐HCC, L‐carnitine promotes tumor progression primarily through its classical role in enhancing fatty acid oxidation (FAO). However, in MASH‐HCC, where FAO is markedly suppressed, L‐carnitine shifts from this canonical function to serve instead as an intracellular acetyl group buffer.
Chuqi Xia, Xiao Zhang, Jinze Li, Ning Xu, Sheng Hu, Qiyu Lu, Yuxuan Li, Taifu Xiao, Xu Li, Xue Wang, Kequan Xu, Daoming Liang   +11 more
wiley   +1 more source

Influence of seam spacing and lateral pressure on deviatoric loading of the withdrawal roadway surrounding rock under the goaf. [PDF]

Sci Rep
Chen D, Tang J, He W, Gao C, Zhang Z.
europepmc   +1 more source

Selective Technology as New Philosophy of Coal Extraction [PDF]

, 2013
Astafyev, Denys, Bondarenko, V.I., Isakova, M.L., Shapovalov, Yakov, Yarkovich, Artyom   +4 more
core  

Non‐Targeting shRNA‐Encoded Plasmid DNA Enhances Protective Immunity Through RIDD‐RIG‐I Signaling Pathway in the Zika Virus Animal Model

Advanced Science, EarlyView.
We present a novel DNA vaccine platform featuring intrinsic, non‐targeting dsRNA that significantly enhances immune responses by activating the regulated IRE1‐dependent decay‐RIG‐I signaling pathway. This research elucidates a previously uncharacterized mechanism for dsRNA‐mediated innate immune activation.
Min‐Syuan Huang, Hung‐Chun Liao, Po Peng, Wan‐Ling Wu, Kit Man Chai, Mei‐Yu Chen, Guann‐Yi Yu, Tsung‐Hsien Chuang, Hsin‐Wei Chen, Chuang‐Rung Chang, Shih‐Jen Liu   +10 more
wiley   +1 more source

Study on the anisotropic characteristics of mechanical properties and energy evolution in layered phyllite. [PDF]

PLoS One
Chen L, Xi B, Zhao N, Dong Y, He S, Liu K, Gao P, Xie J.   +7 more
europepmc   +1 more source

Wafer‐Scale Room‐Temperature Processing of Lead‐Free Perovskites for Optoelectronic Applications

Advanced Science, EarlyView.
We present the first wafer‐scale, room‐temperature synthesis of lead‐free Cs3Sb2X9 (X = Br, I) perovskite films via solvent‐free magnetron sputtering. The resulting high‐performance photodetectors achieve benchmark responsivity, bandwidth, and detectivity, enabling scalable manufacturing for next‐generation optoelectronics.
Rosanna Mastria, Hoi Tung Lam, Ioannis Leontis, Sara Bonomi, Mohammed Ali Saleh Alshehri, Aurora Rizzo, Pietro Galinetto, Maddalena Patrini, Ned Taylor, Steven P. Hepplestone, Monica F. Craciun, Lorenzo Malavasi, Saverio Russo   +12 more
wiley   +1 more source