Results 41 to 50 of about 273,199 (309)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

An Improved Method for Estimating the Strength of Jointed Rock Mass Using Drilling Technology

Geofluids, 2022
During underground excavations for civil and mining engineering purposes, the variations in mechanical properties of jointed rock mass are important, especially for the design of underground structures.
Yong Zhang, Peng Li, Fengyin Liu
doaj   +1 more source

APPLICABILITY OF THE GEOLOGICAL STRENGTH INDEX (GSI) CLASSIFICATION FOR THE TRUSMADI FORMATION AT SABAH, MALAYSIA [PDF]

Earth Science Malaysia, 2020
During the feasibility and preliminary design stages of a project, when very little detailed information on the rock mass and its geomechanic characteristics is not available, the use of a Rock Mass Classification Scheme (RMCS) can be of considerable ...
Rodeano Roslee, Jeffery Anak Pirah, Ahmad Nazrul Madri, Mohd Fauzi Zikiri   +3 more
doaj   +1 more source

Boreholes plans optimization methodology combining geostatistical simulation and simulated annealing [PDF]

, 2017
Nowadays, the prospection plans have the difficult task of ensuring a more complete and rich characterization of the rock mass for the purpose of optimizing costs and increasing safety in geotechnical projects. Currently, boreholes location and depth are
Emery, Xavier, Lamas, Luís, Miranda, Tiago F. S., Pinheiro, Marisa Mota, Rocha, Ana Maria A. C.   +4 more
core   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

All Six Planets Known to Orbit Kepler-11 Have Low Densities

, 2013
The Kepler-11 planetary system contains six transiting planets ranging in size from 1.8 to 4.2 times the radius of Earth. Five of these planets orbit in a tightly-packed configuration with periods between 10 and 47 days.
Agol, Eric, Deck, Katherine M., Fabrycky, Daniel C., Fischer, Debra A., Fortney, Jonathan J., Howell, Steve B., Isaacson, Howard, Jenkins, Jon M., Jontof-Hutter, Daniel, Kolbl, Rea, Lissauer, Jack J., Lopez, Eric D., Marcy, Geoffrey W., Rowe, Jason F., Sasselov, Dimitar, Short, Donald R., Welsh, William F.   +16 more
core   +1 more source

A fractal fragmentation model for rockfalls [PDF]

, 2017
The final publication is available at Springer via http://dx.doi.org/10.1007/s10346-016-0773-8The impact-induced rock mass fragmentation in a rockfall is analyzed by comparing the in situ block size distribution (IBSD) of the rock mass detached from the ...
Corominas Dulcet, Jordi, Mavrouli, Olga Christina, Ruiz Carulla, Roger   +2 more
core   +2 more sources

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Development of Rock Classification Systems: A Comprehensive Review with Emphasis on Artificial Intelligence Techniques

Eng
At the initial phases of tunnel design, information on rock properties is often limited. In such instances, the engineering classification of the rock is recommended as a primary assessment of its geotechnical condition. This paper reviews different rock
Gang Niu, Xuzhen He, Haoding Xu, Shaoheng Dai   +3 more
doaj   +1 more source

BILSTM-Based Deep Neural Network for Rock-Mass Classification Prediction Using Depth-Sequence MWD Data: A Case Study of a Tunnel in Yunnan, China

Applied Sciences, 2023
Measurement while drilling (MWD) data reflect the drilling rig–rock mass interaction; they are crucial for accurately classifying the rock mass ahead of the tunnel face.
Xu Cheng, Hua Tang, Zhenjun Wu, Dongcai Liang, Yachen Xie   +4 more
doaj   +1 more source