Results 31 to 40 of about 31,155 (211)

Stability Analysis on the Long-Term Operation of the Horizontal Salt Rock Underground Storage

Advances in Civil Engineering, 2021
The construction of the vertical cavern in the salt dome deposit can meet the requirements of both storage capacity and tightness. However, if the vertical cavern is still used as the design shape of the salt rock underground storage in the layered salt ...
Chengzhong Zhang, Qiang Zhang, Weiwei Li, Zhanping Song, Junbao Wang   +4 more
doaj   +1 more source

Investigation on Fracture Mechanical Behavior of Salt Rock With Impurities Under Bending Loading-unloading Conditions

工程科学与技术, 2020
Affected by the cyclic injection and production loads of stored energy, the surrounding rock of underground salt cavern gas storage will produce tensile cyclic fatigue damage or even damage.
Jianfeng LIU, Guosheng DING, Qiangxing ZHANG, Zhide WU, Chaofu DENG, Yilin LIAO, Min LUO, Zhiwei ZHOU   +7 more
doaj  

Particle Flow Analysis of Macroscopic and Mesoscopic Failure Process of Salt Rock under High Temperature and Triaxial Stress

Geofluids, 2021
In order to reveal the mechanism of thermal-induced deformation and fracture development of salt rock under high temperature, the particle flow program PFC2D was used to study the triaxial compression failure process of salt rocks under different ...
Haoran Li, Ziheng Wang, Dekang Li, Yajun Zhang   +3 more
doaj   +1 more source

Deformation characteristics of Lop Nur salt rock subgrade filler under influences of temperature

Yantu gongcheng xuebao
To investigate the deformation characteristics of salt rock subgrade filler under the influences of temperature, ensure the stability of salt rock subgrade and promote the resource application of salt rock in subgrade engineering, the characteristics of ...
WANG Chaohui 1, CHEN Shaochang 1, SONG Liang 1, 2, 3, WEN Penghui 1, CHEN Haoyu 1
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Impurity Effects on the Mechanical Properties and Permeability Characteristics of Salt Rock

Energies, 2020
Impure salt rock strata are extensively distributed in China, giving them great significance in the study of the physical properties of impure salt rock for the construction of underground gas storage in salt mines.
Qiangxing Zhang, Jianfeng Liu, Lu Wang, Min Luo, Hejuan Liu, Huining Xu, Hang Zou   +6 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Multimodal Data‐Driven Microstructure Characterization

Advanced Engineering Materials, EarlyView.
A self‐consistent autonomous workflow for EBSP‐based microstructure segmentation by integrating PCA, GMM clustering, and cNMF with information‐theoretic parameter selection, requiring no user input. An optimal ROI size related to characteristic grain size is identified.
Qi Zhang, Santiago Benito, Özge Özgün, Sebastian Weber, Markus Stricker   +4 more
wiley   +1 more source